Comparison of Choroidal Thickness, Foveal Avascular Zone, and Macular Capillary Density in Macular Edema Secondary to Branch Retinal Vein Occlusion Treated with Ranibizumab or Aflibercept—A Prospective Study

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Title:	Comparison of Choroidal Thickness, Foveal Avascular Zone, and Macular Capillary Density in Macular Edema Secondary to Branch Retinal Vein Occlusion Treated with Ranibizumab or Aflibercept—A Prospective Study
Authors:	Huang, Yu-Te;Huang, Yu-Te;Wang, I;Wang, I;林純如;Lin, Shun-Ju;La, Chun-Ting;Lai, Chun-Ting;Hsia, Ning-Yi;Hsia, Ning-Yi;Huan-Sheng, C;Chen, Huan-Sheng;Tie, Peng-Tai;Tien, Peng-Tai;Bair, Henry;Bair, Henry;Li, Jane-Ming;Lin, Jane-Ming;Chen, Wen-Lu;Chen, Wen-Lu;蔡宜佑;Tsai, Yi-Yu
Contributors:	醫學暨健康學院視光學系
Keywords:	aflibercept;branch retinal vein occlusion;enhanced depth imaging optical coherence tomography;foveal avascular zone;macular capillary density;macular edema;optical coherence tomography angiography;ranibizumab.
Date:	2022-4-1
Issue Date:	2023-03-29 01:31:00 (UTC+0)
Publisher:	亞洲大學
Abstract:	This prospective comparative case series aims to compare best-corrected visual acuity (BCVA), retinal microvasculature, and retinal structural changes in patients treated with either ranibizumab or aflibercept for macular edema (ME) secondary to treatment-na?ve branch retinal vein occlusion (BRVO) by optical coherence tomography angiography (OCTA). Ten patients were enrolled with macular capillary density of the superficial capillary plexus (SCP) and deep capillary plexus (DCP) and foveal avascular zone (FAZ) measured in both eyes before and after treatment. Final central retinal thickness and BCVA improved significantly (p < 0.05), and densities of SCP and DCP of BRVO sectors were significantly lower at baseline than fellow eye counterparts and remained persistently lower during treatment, particularly in the aflibercept group (p < 0.05). SCP density, DCP density of both BRVO sectors (p = 0.0001, p < 0.0001), and non-BRVO sectors (p < 0.0001, p < 0.0001) were significantly correlated with final BCVA for diseased eyes. Using multivariate general linear model analysis, and including OCTA parameters only, but not all of the available clinical data, DCP density of BRVO sectors in both eyes was the most predictive factor for final visual outcome (probability p < 0.0001). OCTA offered further qualitative and quantitative evaluation of treatment-na?ve BRVO. Judging by OCTA parameters, not only in the diseased eye but also in the fellow eye, DCP density of BRVO sectors was the most predictive factor of final visual outcome.
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