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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/115311


    Title: Patients with periodontitis are at a higher risk of stroke: A Taiwanese cohort study
    Authors: Hsu, Pei-Wei;Hsu, Pei-Wei;Shen, Yen-Wen;Shen, Yen-Wen;Sya, Syamsiah;Syam, Syamsiah;Lia, Wen-Miin;Liang, Wen-Miin;吳聰能;Wu, Trong-Neng;許瑞廷;Hsu, Jui-Ting;Fuh, Lih-Jyh;Fuh, Lih-Jyh
    Contributors: 醫學暨健康學院健康產業管理學系
    Date: 2022-08-01
    Issue Date: 2023-03-29 01:28:28 (UTC+0)
    Publisher: 亞洲大學
    Abstract: Background: This study aimed to investigate the risk of stroke incidence in patients with periodontitis.

    Methods: Data on patients diagnosed with periodontitis were collected from Taiwan's National Health Insurance Research Database and were matched (1:1) with patients without periodontitis between 2001 and 2010. A multivariable Cox survival model was used to predict stroke between patients with and without periodontitis, and the possibility of confounders. Hazard ratios (HRs) with 95% confidence intervals (CIs) were used to explore the risk of stroke in the case and control groups. Diseases found during the follow-up period were analyzed to determine possible effects on the study. A total of 282 560 periodontitis and nonperiodontitis patients were enrolled, with most subjects aged 40 to 59 years.

    Results: The overall cumulative incidence of stroke was 2.14 times higher in periodontitis than in nonperiodontitis, and the highest HR was in the more than 80 years age group (HR = 9.30; 95% CI, 7.06-12.26). The multivariate Cox model indicated that the adjusted HR (aHR) between the case and control was 2.03 (95% CI, 1.99-2.08), and a higher aHR was associated with hypertension. Atherosclerosis, atrial fibrillation, obesity, kidney disease, anxiety, and gout discovered during follow-up also showed a potential risk of stroke in patients with periodontitis.

    Conclusion: Therefore, this study suggests a high risk of stroke in patients with periodontitis.
    Appears in Collections:[Department of Healthcare Administration] Journal Article

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