Maternal diabetes and childhood cancer risks in offspring: two population-based studies

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Title:	Maternal diabetes and childhood cancer risks in offspring: two population-based studies
Authors:	Huang, Xiwen;Huang, Xiwen;Hanse, Johnni;Hansen, Johnni;Lee, Pei-Chen;Lee, Pei-Chen;Wu, Chia-Kai;Wu, Chia-Kai;Federma, Noah;Federman, Noah;Onyebuchi, A.;Arah, Onyebuchi A.;李中一;LI, CHUNG-YI;Olsen, Jorn;Olsen, Jorn;Ritz, Beate;Ritz, Beate;Hec, Julia E.;Heck, Julia E.
Contributors:	醫學暨健康學院健康產業管理學系
Date:	2022-09-01
Issue Date:	2023-03-29 01:28:03 (UTC+0)
Publisher:	亞洲大學
Abstract:	Background: The effect of maternal diabetes on childhood cancer has not been widely studied. Methods: We examined this in two population-based studies in Denmark (N = 6420 cancer cases, 160,484 controls) and Taiwan (N = 2160 cancer cases, 2,076,877 non-cases) using logistic regression and Cox proportional hazard regression adjusted for birth year, child's sex, maternal age and birth order. Results: Gestational diabetes in Denmark [odds ratio (OR) = 0.98, 95% confidence interval (CI): 0.71-1.35] or type II and gestational diabetes in Taiwan (type II: hazard ratio (HR) = 0.81, 95% CI: 0.63-1.05; gestational diabetes: HR = 1.06, 95% CI: 0.92-1.22) were not associated with cancer (all types combined). In Denmark, maternal type I diabetes was associated with the risk of glioma (OR = 2.33, 95% CI: 1.04-5.22), while in Taiwan, the risks of glioma (HR = 1.59, 95% CI: 1.01-2.50) were elevated among children whose mothers had gestational diabetes. There was a twofold increased risk for hepatoblastoma with maternal type II diabetes (HR = 2.02, 95% CI: 1.02-4.00). Conclusions: Our results suggest that maternal diabetes is an important risk factor for certain types of childhood cancers, emphasising the need for effective interventions targeting maternal diabetes to prevent serious health effects in offspring.
Appears in Collections:	[健康產業管理學系] 期刊論文

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