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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/115290


    Title: In Vitro Antimicrobial Potential of CAPE and Caffeamide Derivatives against Oral Microbes
    Authors: 石尹華;Shih, Yin-Hwa;Hsi, Shih-Min;Hsia, Shih-Min;Chi, Kuo-Chou;Chiu, Kuo-Chou;Wa, Tong-Hong;Wang, Tong-Hong;Chi, Chi-Ying;Chien, Chi-Ying;Li, Po-Jung;Li, Po-Jung;Yueh-Hsiung;Kuo, Yueh-Hsiung;Tzong-Ming, S;Shieh, Tzong-Ming
    Contributors: 醫學暨健康學院健康產業管理學系
    Keywords: antibiotic resistance;biofilm;caffeamide;caffeic acid phenethyl ester (CAPE);minimum bactericidal concentration;minimum inhibitory concentration.
    Date: 2022-04-01
    Issue Date: 2023-03-29 01:27:33 (UTC+0)
    Publisher: 亞洲大學
    Abstract: Caffeic acid phenethyl ester (CAPE) is a natural component isolated from propolis and used in traditional medicine. We aimed to investigate the antimicrobial properties and action mechanism of CAPE and caffeamide derivatives (26G and 36M) against oral disease microbes. We resolved the minimum inhibitory and bactericidal concentrations of 26G and 36M and their stability at different temperatures and pH. We also evaluated their effect on biofilm formation and antibiotic resistance gene expression in methicillin-resistant Staphylococcus aureus (MRSA). Our results revealed that 26G and 36M showed the best anticancer and antimicrobial activities, respectively, compared with the other four caffeamide derivatives. Both 26G and 36M showed heat-dependent decreases in antimicrobial activity. The 36M derivative was stable irrespective of pH, whereas 26G was not stable under high pH conditions. Biofilm formation and antibiotic resistance-related gene expression were consistent with their respective phenotypes. This study provides evidence for the potential application of CAPE and caffeamide derivatives in dental medicine to cure or prevent oral diseases.
    Appears in Collections:[Department of Healthcare Administration] Journal Article

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