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| Title: | Tyrosinase Inhibitors Derived from Chemical Constituents of Dianella ensifolia |
| Authors: | Che, Yu-Chang;Chen, Yu-Chang;Su, Sheng-Han;Su, Sheng-Han;Jheng-Cian, H;Huang, Jheng-Cian;趙哲毅;Chao, Che-Yi;Su, Ping-Jyun;Sung, Ping-Jyun;Che, Yih-Fung;Chen, Yih-Fung;Horng-Huey, K;Ko, Horng-Huey;Yueh-Hsiung;Kuo, Yueh-Hsiung |
| Contributors: | 醫學暨健康學院食品營養與保健生技學系 |
| Keywords: | Asphodelaceae;Dianella ensifolia;flavan;tyrosinase. |
| Date: | 2022-08-01 |
| Issue Date: | 2023-03-29 01:05:49 (UTC+0) |
| Publisher: | 亞洲大學 |
| Abstract: | Dianella ensifolia is a perennial herb with thickened rhizome and is widely distributed in tropical and subtropical regions of Asia, Australia, and the Pacific islands. This plant has the potential to be used as a source of herbal medicine. This study investigated further phytochemistry and tyrosinase inhibitory effect of some constituents isolated from D. ensifolia. Four new flavans, (2S)-4'-hydroxy-6,7-dimethoxyflavan (1), (2S)-3',4'-dihydroxy-7-methoxy-8-methylflavan (2), (2S)-2'-hydroxy-7-methoxyflavan (3), and (2S,1'S)-4-hydroxy-4-(7-methoxy-8-methylchroman-2-yl)-cyclohex-2-enone (4), together with 67 known compounds, including 10 flavans (5-14), 5 flavanones (15-19), 3 flavone (20-22), 5 chalcones (23-27), 3 chromones (28-30), 15 aromatics (31-45), 7 phenylpropanoids (46-52), one lignan (53), 7 steroids (54-60), one monoterpene (61), one diterpene (62), 4 triterpenes (63-66), a carotenoid (67), 2 alkaloids (68 and 69), and 2 fatty acids (70 and 71) were isolated from D. ensifolia. Their structures were elucidated on the basis of physical and spectroscopic data analyses. Moreover, compounds 1-4, 8, 10-15, 20, 21, and 41 were evaluated for their mushroom tyrosinase inhibitory effect. Compounds 11 and 14 strongly inhibited mushroom tyrosinase activity with IC50 values of 8.6 and 14.5 μM, respectively. |
| Appears in Collections: | [食品營養與保健生技學系] 期刊論文
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