Significant Contribution of Interleukin-18 Genotypes to Lung Cancer Risk in Taiwanese

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Title:	Significant Contribution of Interleukin-18 Genotypes to Lung Cancer Risk in Taiwanese
Authors:	WU, MENG-FENG;WU, MENG-FENG;CHE, LI-HSIOU;CHEN, LI-HSIOU;HSIA, NING-YI;HSIA, NING-YI;SHE, YI-CHENG;SHEN, YI-CHENG;SHEN, TE-CHUN;SHEN1, TE-CHUN;Wang, Zhi-Hon;Wang, Zhi-Hong;楊雅甄;Yang, Ya-Chen;BAU, DA-TIAN;BAU, DA-TIAN
Contributors:	醫學暨健康學院食品營養與保健生技學系
Keywords:	Genotype;Taiwan;interleukin-18;lung cancer;polymorphism;smoking.
Date:	2022-07-01
Issue Date:	2023-03-29 01:01:50 (UTC+0)
Publisher:	亞洲大學
Abstract:	Background/aim: The elevated expression of interleukin-18 (IL-18) among lung cancer patients raised our curiosity to examine the role of IL-18 genotypes in lung cancer. Materials and methods: IL-18 -656 (rs1946519), -607 (rs1946518), and -137 (rs187238) genotypes of 358 lung cancer cases and 716 controls were determined via the PCR-RFLP methodology. Results: The distributions of genotypic and allelic frequencies of IL-18 -607, but not those of -656 or -137, were differentially distributed between cases and controls. IL-18 -607 AC and CC genotypes were both lower (45.8% and 16.2%) in lung cancer patients compared to controls (51.4% and 24.7%). In addition, IL-18 -607 AC and CC genotypes were of significantly lower percentages both among non-smokers and smokers. Otherwise, no differential distribution was found regarding IL-18 -656 or -137. Conclusion: IL-18 -607 C allele can serve as a protective predictor for lung cancer risk in Taiwanese.
Appears in Collections:	[食品營養與保健生技學系] 期刊論文

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