SECO-ABIETANOIDS FROM Cryptomeria japonica AND THEIR INHIBITORY ACTIVITY TOWARD XANTHINE OXIDASE

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题名:	SECO-ABIETANOIDS FROM Cryptomeria japonica AND THEIR INHIBITORY ACTIVITY TOWARD XANTHINE OXIDASE
作者:	Chang, Chi-I;Chang, Chi-I;Ch, Cheng-Chi;Chen, Cheng-Chi;Horng-Huey, K;Ko, Horng-Huey;Che, Jih-Jung;Chen, Jih-Jung;Che, Ming-Jen;Cheng, Ming-Jen;趙哲毅;Chao, Che-Yi;郭悅雄;Kuo, Yueh-Hsiung
贡献者:	醫學暨健康學院食品營養與保健生技學系
关键词:	abietane；Cryptomeria japonica；Cupressaceae
日期:	2022-05-01
上传时间:	2023-03-29 01:01:46 (UTC+0)
出版者:	亞洲大學
摘要:	A new seco-abietanoid, 12-methoxy-7-oxo-6,7-secoabieta-8,11,13-trien-6-oic acid (1), and a known seco-abietanoid,12-hydroxy-6,7-secoabieta-8,11,13-triene-6,7-dial (2), were isolated from the methanol extract of the bark of Cryptomeria japonica. Structure determination of the two compounds was accomplished by spectroscopic analyses including 1D and 2D NMR (1H, 13C, COSY, HMQC, HMBC, and NOESY) and EI-MS. At a concentration of 50 μM, the inhibitory effects of compounds 1 and 2 on xanthine oxidase were 30.4 ± 0.9% and 32.0 ± 1.7%, respectively.
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