Contribution of Cyclin-dependent Kinase Inhibitor 1B Genotypes to Childhood Leukemia Risk

ASIA unversity > 醫學暨健康學院 > 食品營養與保健生技學系 > 期刊論文 > Item 310904400/115165

jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://asiair.asia.edu.tw/ir/handle/310904400/115165

题名:	Contribution of Cyclin-dependent Kinase Inhibitor 1B Genotypes to Childhood Leukemia Risk
作者:	PE, JEN-SHENG;PEI, JEN-SHENG;CHA, WEN-SHIN;CHANG, WEN-SHIN;HSU, PEI-CHEN;HSU, PEI-CHEN;CH, CHAO-CHUN;CHEN, CHAO-CHUN;楊雅甄;Yang, Ya-Chen;HSU, SHIH-WEI;HSU, SHIH-WEI;BAU2, DA-TIAN;BAU2, DA-TIAN
贡献者:	醫學暨健康學院食品營養與保健生技學系
关键词:	CDKN1B;Taiwan;childhood leukemia;genotype;polymorphism.
日期:	2022-05-01
上传时间:	2023-03-29
出版者:	亞洲大學
摘要:	Background/aim: Although genetic differences in cell-cycle control genes have been associated with cancer risk, to our knowledge, no report has specifically examined the role of gene variants in childhood acute lymphoblastic leukemia (ALL). Cyclin-dependent kinase inhibitor 1B (CDKN1B; also known as p27/KIP1) is a cell-cycle regulating gene. This study aimed at investigating the association between CDKN1B genotypes and childhood ALL risk. Materials and methods: In 266 childhood ALL cases and 266 healthy controls, the CDKN1B rs34330 and 2066827 polymorphisms were genotyped, and the association of CDKN1B genotypes with childhood ALL risk were analyzed. Results: The genotypes of CDKN1B rs34330 and 2066827 were similarly distributed between the control and case groups (p for trend=0.8718 and 0.4030, respectively). The allelic frequency also exhibited no statistical difference (p=1.0000 and 0.6666, respectively). There was no significant interaction between CDKN1B genotypes and age or sex. Conclusion: CDKN1B genotypes were not found to be minor contributors to childhood ALL susceptibility in Taiwan.
显示于类别:	[食品營養與保健生技學系] 期刊論文

文件中的档案:

档案	描述	大小	格式	浏览次数
index.html		0Kb	HTML	156	检视/开启

在ASIAIR中所有的数据项都受到原著作权保护.

数据加载中.....