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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/115165


    Title: Contribution of Cyclin-dependent Kinase Inhibitor 1B Genotypes to Childhood Leukemia Risk
    Authors: PE, JEN-SHENG;PEI, JEN-SHENG;CHA, WEN-SHIN;CHANG, WEN-SHIN;HSU, PEI-CHEN;HSU, PEI-CHEN;CH, CHAO-CHUN;CHEN, CHAO-CHUN;楊雅甄;Yang, Ya-Chen;HSU, SHIH-WEI;HSU, SHIH-WEI;BAU2, DA-TIAN;BAU2, DA-TIAN
    Contributors: 醫學暨健康學院食品營養與保健生技學系
    Keywords: CDKN1B;Taiwan;childhood leukemia;genotype;polymorphism.
    Date: 2022-05-01
    Issue Date: 2023-03-29
    Publisher: 亞洲大學
    Abstract: Background/aim: Although genetic differences in cell-cycle control genes have been associated with cancer risk, to our knowledge, no report has specifically examined the role of gene variants in childhood acute lymphoblastic leukemia (ALL). Cyclin-dependent kinase inhibitor 1B (CDKN1B; also known as p27/KIP1) is a cell-cycle regulating gene. This study aimed at investigating the association between CDKN1B genotypes and childhood ALL risk.

    Materials and methods: In 266 childhood ALL cases and 266 healthy controls, the CDKN1B rs34330 and 2066827 polymorphisms were genotyped, and the association of CDKN1B genotypes with childhood ALL risk were analyzed.

    Results: The genotypes of CDKN1B rs34330 and 2066827 were similarly distributed between the control and case groups (p for trend=0.8718 and 0.4030, respectively). The allelic frequency also exhibited no statistical difference (p=1.0000 and 0.6666, respectively). There was no significant interaction between CDKN1B genotypes and age or sex.

    Conclusion: CDKN1B genotypes were not found to be minor contributors to childhood ALL susceptibility in Taiwan.
    Appears in Collections:[Department of Food Nutrition and Healthy Biotechnology] Journal Article

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