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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/115160


    Title: Clinical Effects of PET-CT Before Definite Concurrent Chemoradiotherapy in Patients With Unresectable Stage IIIA–IIIB Squamous Cell Carcinoma of the Lungs
    Authors: Lin, Wei-Chun;Lin, Wei-Chun;Chen, Wang-Mi;Chen, Wang-Ming;Mingchi, Chen;Mingchih, Chen;Shia, Ben-Cha;Shia, Ben-Chang;吳思遠;Wu, Szu-Yuan
    Contributors: 醫學暨健康學院食品營養與保健生技學系
    Date: 2022-06-01
    Issue Date: 2023-03-29
    Publisher: 亞洲大學
    Abstract: Purpose: No large-scale, retrospective cohort study with a long-term follow-up time has yet evaluated the effects of preoperative 18 F-FDG PET-CT on survival in patients with unresectable stages IIIA-IIIB squamous cell lung carcinoma (SqCLC) who received definite concurrent chemoradiotherapy (CCRT).

    Methods: We included patients with unresectable stages IIIA-IIIB SqCLC receiving definite CCRT and categorized them into 2 groups. The case group comprised patients who underwent pre-CCRT 18 F-FDG PET-CT, and the comparison group comprised patients who did not receive pre-CCRT 18 F-FDG PET-CT; the groups were matched at a ratio of 1:1.

    Results: The matching process yielded a final cohort of 4042 eligible patients (2021 and 2021 in the case and comparison groups, respectively). Multivariable Cox regression analyses revealed a positive correlation between patients with unresectable stages IIIA-IIIB SqCLC receiving definite CCRT and all-cause death in the pre-CCRT 18 F-FDG PET-CT (adjusted hazard ratio, 0.85; 95% confidence interval, 0.80-0.91; P < 0.0001).

    Conclusion: Pre-CCRT 18 F-FDG PET-CT was associated with more favorable survival in both patients with unresectable clinical stage IIIA and those with stage IIIB receiving definite CCRT.
    Appears in Collections:[Department of Food Nutrition and Healthy Biotechnology] Journal Article

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