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| Title: | Evaluation of antioxidant, anti-inflammatory, and anti-hyperglycemic effects of Wattakaka volubilis Linn. f |
| Authors: | Maya, M.R.;Maya, M.R.;Rameshkum, K.;Rameshkumar, K.;Veeramani, V.;Veeramanikandan, V.;Boobalan, T.;Boobalan, T.;Kumar, M.;Kumar, M.;Eyini, M.;Eyini, M.;Arun, A.;Arun, A.;Arivalagan, P;Pugazhendhi, Arivalagan;Balaji, P.;Balaji, P. |
| Contributors: | 研究發展處學術發展組 |
| Keywords: | Phytochemical profiling；Anti-oxidant；Anti-inflammatory；Anti-hyperglycemic；Wattakaka volubilis |
| Date: | 2022-01-01 |
| Issue Date: | 2023-03-28 02:25:25 (UTC+0) |
| Publisher: | 亞洲大學 |
| Abstract: | The phytochemicals, antioxidants, antiinflammatory and the anti-hyperglycemic properties of Wattakaka volubilis Linn. F were determined. The Hot Water Extract (HWE) and Acetone Extracts (AE) of W. volubilis leaves were tested for a variety of phytochemicals. The preliminary analysis revealed the presence of a large number of phytochemicals. The DPPH assay was used to measure the free radical scavenging activity of both HWE and AE. The HWE had the highest DPPH scavenging rate (87.72 %t), followed by the AE (33.33 %). At 500?g/mL concentration, the anti-inflammatory activity of HWE, AE, and Diclofenac (standard drug) was 54.27 %, 49.88 %, and 83.33 %, respectively. Orally administered alloxan (75?mg/kg body weight) resulted in a significant (p 0.05) decrease in blood glucose levels in diabetic mice with HWE and AE at 200?mg/kg b.wt for 4 weeks. Aside from all hypoglycemic parameters, the histopathology of the pancreas was also controlled, indicating that HWE exerted greater anti-diabetic activity than AE. Furthermore, HWE supported a significant inhibition of -amylase enzyme activity, with the highest action of 99.23 % reticence at 1000?g/mL. The findings indicate that HWE has a potential antidiabetic effect; thus, HWE may be a non-hazardous traditional and complementary medicine in treating hyperglycemia and related problems, substantiating as an anti-hyperglycemic agent. |
| Appears in Collections: | [研究發展處] 期刊論文
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