Development in nanotechnology and its biological application have progressively contributes to the interaction of nanoparticles with cells which helps in treating/diagnosing cancer like diseases. In order to understand the morphological transformation of drug nanoparticles interaction on cancerous cells, we prepared curcumin nanorods (CNRs) and curcumin nanospheres (CNSs) by antisolvent precipitation process. The size, surface charge and morphology were analyzed by Dynamic Light Scattering (DLS) and High Resolution Transmission Microscope (HRTEM). The size of both the nanoparticles ranges below 50?nm and the zeta potential showed the negative surface charge. Powder X-ray Diffraction (PXRD) and Fourier Transformer Infra-Red spectroscopy (FTIR) studies revealed the crystal systems (monoclinic and orthorhombic forms) of curcumin nanoparticles. The cytotoxicity of these drugs was tested using MTT assay, where CNRs exhibited a little more anticancer activity and apoptosis than CNSs in HepG2 cells. Hence, we suggest that the morphological variation may act as another factor, which influences apoptotic cell death in spite of the surface charge.
