血管相關因子對於失智症發生的預測： 回溯性研究

ASIA unversity > 醫學暨健康學院 > 心理學系 > 博碩士論文 > Item 310904400/113663

Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/113663

Title:	血管相關因子對於失智症發生的預測：回溯性研究 Predictive values of vascular- related factors on incident dementia: A retrospective study
Authors:	樊松嫚 FAN, SUNG-MAN
Contributors:	心理學系
Keywords:	高血壓、糖尿病與高膽固醇血症為常見血管風險因子，也為老年人中常見的慢性疾病。這些血管風險因子會引起血管構造的改變，常與動脈粥狀硬化、心臟疾病、中風等多種疾病共病，亦增加失智的風險。過去許多研究探討心血管風險因子與生活習慣如何導致失智症的發生，然而研究發現並不一致，不同的結果可能由於血管和生活習慣相關因素之間的複雜交互作用。此外，過去在不同人群的研究中，其結果的普遍性仍須進一步驗證。本研究目的為評估血管與生活習慣相關因素對於失智風險的預測。研究使用「秀傳醫療體系失智症登錄資料庫」，此資料庫提供長期追蹤且具回顧性的數據，從中選取無失智症並接受兩次檢查的參與者 (N = 1,285)。使用可控制共變量的Cox比例風險模型 (cox proportional hazard model)，評估血管和生活習慣相關因素對於失智、阿茲海默型失智 (dementia of the Alzheimer’s type, DAT)與血管型失智 (vascular dementia, VaD)風險之預測。控制共變量後，高膽固醇血症與降低失智及DAT風險相關，而茹素與高血壓則能正向預測VaD。此結果表明失智的臨床預測指標，未來以社區人口為樣本的研究中還需檢驗此結果的普遍性。 Hypertension, diabetes, and hypercholesterolemia are common diseases related to vascular risks in the elderly age. These diseases can cause changes in vascular structure, and are commonly comorbid with atherosclerosis, heart diseases and stroke. Furthermore, these vascular-related factors often increase the risk of dementia. Many previous studies have explored the predictive values of these vascular-related factors and lifestyle-related factors on incident dementia. However, the results are inconsistent. The inconsistent findings may be due to complex interactions among vascular- and lifestyle-related factors. In addition, the generalizability of findings in previous studies across different populations awaits further validation. The aim of this study is to estimate the risk of vascular- and lifestyle-related factors in predicting incident dementia. I used the History-based Artificial Intelligent Clinical Dementia Diagnosis System (HAICDDS) from Show Chwan Healthcare System, a retrospectively longitudinal database, to select participants without prevalent dementia and received two examinations (N = 1,285). Risks of incident all-cause dementia, dementia of the Alzheimer’s type (DAT), and vascular dementia (VaD) predicted by vascular- and lifestyle-related factors were assessed by using Cox proportional hazards regression models controlling covariates. Hypercholesterolemia was associated with decreased risks for incident all-cause dementia and DAT after controlling the covariates. Consuming vegetarian diets was associated with increased risk for incident all-caused dementia and VaD after controlling the covariates. These findings indicated clinically predictive markers for incident dementia. Future study in community is required to test the generalizability of the findings.
Date:	2022-07-15
Issue Date:	2022-10-31 03:08:35 (UTC+0)
Publisher:	亞洲大學
Abstract:	失智症;高膽固醇血症;高血壓;可調控因子;茹素 dementia;hypercholesterolemia;hypertension;modifiable factors;vegetarian diet
Appears in Collections:	[心理學系] 博碩士論文

Files in This Item:

File	Description	Size	Format
index.html		0Kb	HTML	98	View/Open

Loading...