性別調節塑化劑殘留對兒童認知功能的影響 -系統性回顧與後設分析

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Title:	性別調節塑化劑殘留對兒童認知功能的影響 -系統性回顧與後設分析 Effects of gender-modulated plasticizer residues on children's cognitive functions - a systematic review and meta-analysis
Authors:	陳靖凱 Chen, Jing-Kai
Contributors:	心理學系
Keywords:	研究背景與目標：塑化劑是一種廣泛使用的鄰苯二甲酸酯類(Plasticizer, phthalate acid)。因用途廣泛且易取得，其常見於塑膠製品（如：餐盒）的物質殘留隱憂也需關注。塑化劑殘留(residue)與認知功能(cognitive function）的研究指出，若殘留體內的濃度越高，可能使孩童在未來發展認知功能，如智力(intelligence)與執行功能，以及注意力有不良影響。此外，性別角色可能作為保護因子，調節塑化劑殘留對於認知功能的影響。本研究欲以系統性回顧與後設分析討論性別與塑化劑殘留對兒童認知功能的影響。欲探討：(1) 性別、塑化劑殘留濃度與兒童於認知功能之影響。(2) 性別是否扮演調節塑化劑殘留濃度對兒童認知表現之角色。研究方法：透過 PubMed、PROQUEST 及 SpringerLink 等資料庫搜尋相關文獻，其所使用的關鍵字包含(1) Phthalates (2) Child 或 Preschool 或 Infant 或 Teenager(3) Cognitive function 或 Intelligence 或 Executive function 等，共三類。初級納入的文獻為 2752 篇，經 PRISMA(Preferred Reporting Items for Systematic Reviews and Meta-Analyses)流程篩選後，納入 12 篇文獻進行數據分析。結果：在塑化劑殘留兒童的認知功能文獻中，性別因子在 Bayley 嬰幼兒發展量表上有達顯著差異；智力量表（魏氏系列或智力發展量表）則無顯著差異。因塑化劑殘留濃度，認知功能數據難以統一單位進行分析，因此僅能針對性別差異分析兩篇。但 12 篇文獻中有 9 篇指出塑化劑殘留濃度與認知功能表現負相關。最後，性別因子在塑化劑殘留濃度與認知功能之影響上，當塑化劑（如：MEHHP及MEOHP）濃度越低時，其性別之認知功能表現差異越明顯。討論：共 12 篇文獻指出，塑化劑殘留量與性別兩因子皆會影響兒童的認知功能表現，其中女性可作為認知功能表現的保護因子。然因為納入研究因符合納入標準之文獻少且無統一的濃度分析單位，且多為觀察性而非對照研究，本研究分析指出之結果推論仍應小心解讀。 Background: Plasticizers are chemicals used daily, collectively known as phthalates in chemistry. The hidden concerns caused by material residues are essential.The literature on plasticizer residues and cognitive functions shows that if the concentration of plasticizer residues in the body is higher, it may adversely affect the development of children's intelligence and attention. In addition, some studies have pointed out that the degree of influence of plasticizer residues on cognitive functions varies with gender. The research aimed to find (1) whether gender and age have differences in cognitive function and (2) whether higher concentrations of plasticizers make cognitive function worse.Methods: Search relevant literature through PubMed, PROQUEST, and SpringerLinkdatabases.The keywords used include three categories (1) Phthalates, (2) Child or Preschool or Infant or Teenager, and (3) Cognitive function or Intelligence or Executive function. The primary included literature was 2752;after screening by the PRISMA process, the remaining samples were 12.Result and Discussion: The cognitive functions of males and females have significant on the Bayley scale, but no significant differences were found on the Intelligence and Development Scale or the Wechsler Intelligence Scale series, which cannot be ruled out due to the small sample size (2 data was included);this section should be interpreted carefully. The analysis shows that when the concentration of plasticizers (such as MEHHP and MEOHP) is lower, the cognitive function in female is more prominent than in male. Nine out of 12 articles showed that plasticizer residue was negatively correlated with cognitive functions. In addition, plasticizer residues have a more significant effect on males.
Date:	2022-07-15
Issue Date:	2022-10-31 03:08:31 (UTC+0)
Publisher:	亞洲大學
Abstract:	塑化劑;認知功能;兒童;智力發展量表;Bayley 量表;魏式智力量表 Phthalates;Cognitive Ability;Children;Intelligence and Development Scales;Bayley Scales of Infant and Toddler Development;Wechsler Intelligence Scale
Appears in Collections:	[心理學系] 博碩士論文

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