以?聚糖和氧化透明質酸作為人工神經導管之研究

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Title:	以?聚糖和氧化透明質酸作為人工神經導管之研究 Nerve guide conduit development based on chitosan and oxidized hyaluronic acid
Authors:	林壹晟 LIN, YI-CHENG
Contributors:	生物資訊與醫學工程學系
Keywords:	殼聚糖;神經導管;神經的再生和修復;周邊神經損傷;氧化透明質酸 Chitosan;Nerve guide conduits;Repair and regeneration of nerves;Peripheral nerve injury;Oxidized hyaluronic acid
Date:	2022-07-25
Issue Date:	2022-10-31 02:53:45 (UTC+0)
Publisher:	亞洲大學
Abstract:	受損神經的修復和再生仍然是現在生物醫學中所面臨的巨大挑戰之一，即使對周邊神經損傷的病理、生理學和再生機制有廣泛的了解，但卻無法確保完全性的功能恢復，並且周邊神經的受損在運動以及感覺上一定程度影響人類的生活，迄今為止，為了解決這一類問題提出了很多替代的治療方法，其中一個是神經導管。神經導管是由天然以及合成生物聚合物所製成的管狀結構，被設計成具有神經再生所需的機械性質，保護和結構。神經導管可以充當受損神經端對端之間的橋樑，為兩端提供引導、保護和營養的支持，防止周圍的組織入侵以及提供軸突生長的方向以輔助神經的再生。本研究中，我們致力於使用簡單的傳統工藝方法將天然生物聚合物的材料製成導管的結構，提供能夠使神經軸突修復和生長的環境。在這裡我們使用天然聚合物殼聚糖以及氧化透明質酸製成雙層結構的神經導管，兩種材料都具備一定的生物降解與良好的生物相容性和無毒性，並且在組織工程及再生醫學領域已被廣泛運用，本研究旨在結合殼聚糖本身具有的機械特性和抗菌特性與氧化透明質酸所擁有柔軟易操作的性質，建構一個能夠提供支撐、保護、生長環境和滲透率的神經導管。 Repair and regeneration of nerves injury remains one of the great challenges in biomedicine. Even researchers have already understood the pathology, physiology, and regeneration mechanisms of peripheral nerve injury extensively, we still cannot recover nerve’s function completely. In addition, the damage of peripheral nerves affects human life to a certain extent in terms of movement and sensation. To date, many alternative treatments have been proposed for nerve regeneration, one of which is nerve conduits. Nerve conduits are tubular structures made of natural and synthetic biopolymers designed to possess the mechanical properties, protection and structure required for nerve regeneration. Nerve conduits can act as an end-to-end bridge between damaged nerves, providing guidance for axonal growth, protection, and nutrition support for both ends, preventing invasion of surrounding tissue, and assist nerve regeneration. In this study, we focused on the use of simple traditional processes to fabricate natural biopolymer materials into conduit structures that provide an friendly environment that enables axonal repair and growth. Here we use natural polymer chitosan and oxidized hyaluronic acid to make a double-layered nerve conduit. Both materials have specific advantages, such as biodegradable, well biocompatibility and non-toxicity, and they are suitable used tissue engineering and regeneration. This study aims to combine the mechanical and antibacterial properties of chitosan itself with the soft and easy-to-handle properties of oxidized hyaluronic acid to construct a nerve conduit that can provide support, protection, growth environment and permeability.
Appears in Collections:	[生物資訊與醫學工程學系 ] 博碩士論文

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