牛樟芝複方膠囊護肝功能評估

ASIA unversity > 醫學暨健康學院 > 食品營養與保健生技學系 > 博碩士論文 > Item 310904400/113283

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题名:	牛樟芝複方膠囊護肝功能評估 Evaluation of Antrodia camphorata Capsule for Protecting Liver Function
作者:	張志皇 CHANG, CHIH-HUANG
贡献者:	食品營養與保健生技學系
关键词:	牛樟芝;保護肝臟;乙醯胺酚;發炎 A. camphorata;APAP;Liver protection;inflammation
日期:	2022
上传时间:	2022-06-15 07:05:34 (UTC+0)
出版者:	亞洲大學
摘要:	牛樟芝是一種蘑菇，在亞洲國家廣泛用於預防和治療各種疾病，包括肝臟疾病。然而，有助於生物功能的活性成分仍然難以捉摸。本研究的目的是測試牛樟芝膠囊在小鼠急性肝損傷模型中的保肝作用。在小鼠乙醯胺酚（Acetaminophen; APAP）誘導前，小鼠每天口服牛樟芝膠囊，持續 6 天。由結果發現牛樟芝膠囊降低天門冬氨酸轉氨酶 (AST)、丙氨酸轉氨酶 (ALT)活性對小鼠乙醯胺酚肝毒性。此外，牛樟芝膠囊可以通過抑制乙醯胺酚誘導的急性肝損傷中活化的巨噬細胞產生的促炎細胞因子來減少肝臟組織病理學變化並具有抗發炎活性。結果證據證明，牛樟芝膠囊可通過降低氧化壓力和發炎的產生來保護肝細胞免受乙醯胺酚誘導的肝毒性，牛樟芝膠囊確實具有保護肝臟的效果。 Antrodia Camphorate is a mushroom that is widely used in Asian countries to prevent and treat various diseases, including liver diseases. However, the active ingredients that contribute to biological functions are still elusive. The purpose of this study is to test the hepatoprotective effect of A. camphorata capsules in a mouse model of acute liver injury. Before the induction of Acetaminophen (APAP) in mice, the mice were given oral A. camphorata capsules every day for 6 days. The results showed that A. cinnamomea capsules reduced the activity of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) on the liver toxicity of acetaminophen in mice. In addition, A. cinnamomea capsules can reduce liver histopathological changes and have anti-inflammatory activity by inhibiting the pro-inflammatory cytokines produced by activated macrophages in acute liver injury induced by acetaminophen. The results proved that A. cinnamomea capsules can protect liver cells from acetaminophen-induced hepatotoxicity by reducing the production of oxidative stress and inflammation. A. cinnamomea capsules do have the effect of protecting the liver.
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