Andrographolide mitigates cardiac apoptosis to providecardio-protection in high-fat-diet-induced obese mice

ASIA unversity > 醫學暨健康學院 > 醫學檢驗暨生物技術學系 > 期刊論文 > Item 310904400/113081

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Title:	Andrographolide mitigates cardiac apoptosis to providecardio-protection in high-fat-diet-induced obese mice
Authors:	Lin, Kuan-Ho;Lin, Kuan-Ho;Martha, Shibu;Asokan, Shibu Marthandam;Kuo, Wei-Wen;Kuo, Wei-Wen;謝宥諒;Hsieh, You-Liang;Chong-Kuei, L;Lii, Chong-Kuei;Vijayapadma;Viswanadha, Vijayapadma;Lin, Yi-Lin;Lin, Yi-Lin;Wang, Shulin;Wang, Shulin;Yang, Caixian;Yang, Caixian;黃志揚;Huang, Chih-Yang
Contributors:	醫學檢驗暨生物技術學系
Keywords:	Andrographis paniculata;cardiac apoptosis;cell survival;high fat diet;obesity.
Date:	2020-01
Issue Date:	2020-10-15 06:28:07 (UTC+0)
Publisher:	亞洲大學
Abstract:	Excessive intake of high fat diet (HFD) and associated obese conditions are critical contributors of cardiac diseases. In this study, an active metabolite andrographolide from Andrographis paniculata was found to ameliorate HFD-induced cardiac apoptosis. C57/BL6 mouse were grouped as control (n = 9), obese (n = 8), low dose (25 mg/kg/d) andrographolide treatment (n = 9), and high dose (50 mg/kg/d) andrographolide treatment (n = 9). The control group was provided with standard laboratory chow and the other groups were fed with HFD. Andrographolide was administered through oral gavage for 1 week. Histopathological analysis showed increase in apoptotic nuclei and considerable cardiac-damages in the obese group signifying cardiac remodeling effects. Further, Western blot results showed increase in pro-apoptotic proteins and decrease in the proteins of IGF-1R-survival signaling. However, feeding of andrographolide significantly reduced the cardiac effects of HFD. The results strongly suggest that andrographolide supplementation can be used for prevention and treatment of cardiovascular disease in obese patients.
Relation:	ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
Appears in Collections:	[醫學檢驗暨生物技術學系] 期刊論文

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