The Association of MMP7 Genotype With Pterygium

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題名:	The Association of MMP7 Genotype With Pterygium
作者:	HU, PEI-SHIN HU, PEI-SHIN WANG, YUN-CHI WANG, YUN-CHI LI, CHENG-HSI LIAO, CHENG-HSI HSIA, NING-YI HSIA, NING-YI WU, MENG-FENG WU, MENG-FENG YAN, JAI-SING YANG, JAI-SING CHIEN-CHIH, Y YU, CHIEN-CHIH CHA, WEN-SHIN CHANG, WEN-SHIN PEI-SHIN HU;PEI-SHIN HU;YUN-CHI WANG;YUN-CHI WANG;CHENG-HSI LI;CHENG-HSI LIAO;NING-YI HSIA;NING-YI HSIA;MENG-FENG WU;MENG-FENG WU;JAI-SING YAN;JAI-SING YANG;CHIEN-CHIH Y;CHIEN-CHIH YU;WEN-SHIN CHA;WEN-SHIN CHANG;包大?;Da-Tian Bau;CHIA-WEN TSA;CHIA-WEN TSAI Bau, Da-Tian TSA, CHIA-WEN TSAI, CHIA-WEN
貢獻者:	資訊電機學院生物資訊與醫學工程學系
關鍵詞:	Age;gender;genotype;MMP7;polymorphism;pterygium Taiwan
日期:	2020-01-20
上傳時間:	2020-10-14 05:45:41 (UTC+0)
出版者:	亞洲大學
摘要:	Background/Aim: In literature, few studies have examined the diagnostic or prognostic potential of matrix metalloproteinases (MMP) in pterygium, whose formation and progression are closely related to imbalance in the extracellular microenvironment. In this study, we investigated the contribution of MMP7 promoter (A-181G and C-153T) polymorphic genotypes to pterygium risk. Materials and Methods: A total of 134 cases and 268 controls were collected and their MMP7 genotypes at A-181G and C-153T were examined by polymerase chain reaction-restriction fragment length polymorphism methodology. Results: The AA, AG and GG genotypes at MMP7 promoter A-181G were non-significantly differentially distributed between the two groups at 85.8, 11.2 and 3.0%, respectively, in pterygium cases and 88.4, 9.7 and 1.9% in controls, respectively (p for trend=0.6822). There was no polymorphic genotype for MMP7 C-153T among our Taiwanese cohort. Conclusion: A-181G and C-153T genotypes at MMP7 do not have a direct role in determining Taiwanese susceptibility to pterygium.
關聯:	IN VIVO
顯示於類別:	[生物資訊與醫學工程學系 ] 期刊論文

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