Therapeutic Efficacy Evaluation of Pegylated Liposome Encapsulated With Vinorelbine Plus 111In Repeated Treatments in Human Colorectal Carcinoma With Multimodalities of Molecular Imaging

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題名:	Therapeutic Efficacy Evaluation of Pegylated Liposome Encapsulated With Vinorelbine Plus 111In Repeated Treatments in Human Colorectal Carcinoma With Multimodalities of Molecular Imaging
作者:	CHIE, YI-CHUN CHIEN, YI-CHUN YING-HSIANG CHOU, YING-HSIANG WAN, WEI-HSUN WANG, WEI-HSUN JOHN, CHUN-HA CHEN, JOHN CHUN-HAO CHA, WEN-SHIN CHANG, WEN-SHIN TSA, CHIA-WEN TSAI, CHIA-WEN 包大? Bau, Da-Tian HW, JENG-JONG HWANG, JENG-JONG
貢獻者:	資訊電機學院生物資訊與醫學工程學系
關鍵詞:	Biodistribution;bioluminescence;colorectal cancer;PEGliposome;pharmacokinetics;micro positron emission tomography
日期:	2020-01-20
上傳時間:	2020-10-14 05:44:21 (UTC+0)
出版者:	亞洲大學
摘要:	Background/Aim: In precision therapy, liposomal encapsulated chemotherapeutic drugs have been developed to treat cancers by achieving higher drug accumulation in the tumor compared to normal tissues/organs. Materials and Methods: We developed a novel chemoradiotherapeutic approach via nanoliposomes conjugated with vinorelbine (VNB) and 111In (111In-VNB-liposome) and examined their pharmacokinetics, biodistribution, maximum tolerance dose, and toxicity in a NOD/SCID mouse model. Results: Pharmacokinetic results showed that the area under the curve (AUC) of PEGylated liposomes was about 17-fold higher than that of the free radioisotope. Tumor growth inhibition by 111In-VNB-liposome was significantly higher than that of the control (p<0.05). Conclusion: The tumors in NOD/SCID mice bearing HT-29/tk-luc xenografts were significantly suppressed by 111In-VNB-liposomes. The study proposed repeated treatments with a novel liposome-mediated radiochemotherapy and validation of therapeutic efficacy via imaging.
關聯:	Cancer Genomics & Proteomics
顯示於類別:	[生物資訊與醫學工程學系 ] 期刊論文

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