Dipeptide IF prevents the effects of hypertension-induced Alzheimer's disease on long-term memory in the cortex of spontaneously hypertensive rats

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題名:	Dipeptide IF prevents the effects of hypertension-induced Alzheimer's disease on long-term memory in the cortex of spontaneously hypertensive rats
作者:	Ch, Yung-Ming;Chang, Yung-Ming;Kum, K. Ashok;Kumar, K. Ashok;Ju, Da-Tong;Ju, Da-Tong;Tsung-Jung, H;Ho, Tsung-Jung;Mahalaksh, B.;Mahalakshmi, B.;Lin, Wan-Teng;Lin, Wan-Teng;Hsua, Cecilia;Day, Cecilia Hsuan;Pa, V. Vijaya;Padma, V. Vijaya;Li, Po-Hsiang;Liao, Po-Hsiang;黃志揚;Huang, Chih-Yang
貢獻者:	醫學檢驗暨生物技術學系
關鍵詞:	Alzheimer's disease;amyloid beta angiotensin‐converting enzyme;hypertension;long‐term memory
日期:	2019-12
上傳時間:	2020-09-04 05:56:01 (UTC+0)
出版者:	亞洲大學
摘要:	Hypertension (HTN) is one of the most prevalent chronic conditions; it can damage blood vessels and rupture blood vessels can trap in small vessels. This blockage can prevent blood flow and oxygen delivery to brain cells and can result in Alzheimer's disease (AD). HTN‐ and AD‐mediated long‐time memory loss and its treatment remain poorly understood. Plant‐derived natural compounds are alternative solutions for effectively treating diseases without any side effects. This study revealed that bioactive peptides extracted from potato hydrolysis suppress HTN‐mediated long‐term memory (LTM) loss and cell apoptosis, thus improving memory formation and neuronal cell survival in the spontaneously hypertensive rat (SHR) rat model. SHR rats were treated with bioactive peptide IF (10 mg/kg orally) and angiotensin‐converting enzyme inhibitors (5 mg/kg orally). In this study, we evaluated the molecular expression levels of BDNF‐, GluR1‐, and CREB‐mediated markers protein expression in 24‐week‐old SHR rats. The study result showed that HTN‐induced AD regulated long‐term memory (LTM) loss and neuronal degeneration in the SHR animals. The bioactive peptide‐treated animals showed an elevated level of survival proteins. Bioactive peptide IF activate CREB‐mediated downstream proteins to regulate synaptic plasticity and neuronal survival in the SHR rat model.
關聯:	ENVIRONMENTAL TOXICOLOGY
顯示於類別:	[醫學檢驗暨生物技術學系] 期刊論文

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