Garcimultiflorone K inhibits angiogenesis through Akt/eNOS- and mTOR-dependent pathways in human endothelial progenitor cells

ASIA unversity > 醫學暨健康學院 > 醫學檢驗暨生物技術學系 > 期刊論文 > Item 310904400/112876

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题名:	Garcimultiflorone K inhibits angiogenesis through Akt/eNOS- and mTOR-dependent pathways in human endothelial progenitor cells
作者:	Yang, Chen-Yu;Yang, Chen-Yu;Chen, Chi;Chen, Chi;Cheng-Yung, L;Lin, Cheng-Yung;Che, Yi-Hsuan;Chen, Yi-Hsuan;Li, Chih-Yang;Lin, Chih-Yang;Chi, Chih-Wen;Chi, Chih-Wen;Chen, Yu-Jen;Chen, Yu-Jen;Li, Shih-Chia;Liu, Shih-Chia;Cha, Ting-Kuo;Chang, Ting-Kuo;湯智昕;Chih-Hsin, Tang
贡献者:	醫學檢驗暨生物技術學系
关键词:	Garcimultiflorone K;Angiogenesis;Signaling pathway
日期:	2019-11
上传时间:	2020-09-01 06:51:14 (UTC+0)
出版者:	亞洲大學
摘要:	Background Garcimultiflorone K is a novel polyprenylated polycyclic acylphloroglucinol isolated from the stems of Garcinia multiflora that exhibits promising anti-angiogenic activity in human endothelial progenitor cells (EPCs). Purpose This study sought to determine the underlying anti-angiogenic mechanisms and pharmacological properties of garcimultiflorone K. Methods We examined the anti-angiogenic effects of garcimultiflorone K and its mechanisms of action using in vitro EPC models and in vivo zebrafish embryos. Results EPCs proliferation, migration, differentiation and capillary-like tube formation were effectively and concentration-dependently inhibited by garcimultiflorone K without any signs of cytotoxicity. Our investigations revealed that garcimultiflorone K suppressed EPCs angiogenesis through Akt, mTOR, p70S6K, and eNOS signaling cascades. Notably, garcimultiflorone K dose-dependently impeded angiogenesis in zebrafish embryos. Conclusion Our data demonstrate the anti-angiogneic effects of garcimultiflorone K in both in vitro and in vivo models. Garcimultiflorone K appears to have potential in the treatment of angiogenesis-related diseases.
關聯:	PHYTOMEDICINE
显示于类别:	[醫學檢驗暨生物技術學系] 期刊論文

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