ASIA unversity:Item 310904400/112873
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 94286/110023 (86%)
造访人次 : 21692099      在线人数 : 740
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://asiair.asia.edu.tw/ir/handle/310904400/112873


    题名: Impact of WNT1-inducible signaling pathway protein-1 (WISP-1) genetic polymorphisms and clinical aspects of breast cancer.
    作者: Wang, Yan;Wang, Yan;Yang, Shi-Hui;Yang, Shi-Hui;Hsu, Ping-Wen;Hsu, Ping-Wen;Chien, Szu-Yu;Chien, Szu-Yu;Wan, Chao-Qun;Wang, Chao-Qun;Su, Chen-Ming;Su, Chen-Ming;Do, Xiao-Fang;Dong, Xiao-Fang;Zh, Yong-Ming;Zhao, Yong-Ming;湯智昕;Chih-Hsin, Tang
    贡献者: 醫學檢驗暨生物技術學系
    关键词: breast cancer;single nucleotide polymorphism;WISP-1
    日期: 2019-11
    上传时间: 2020-09-01 06:47:11 (UTC+0)
    出版者: 亞洲大學
    摘要: Breast cancer is the most common diagnosed malignancy in women. This study genotyped blood samples from 236 Han Chinese women with breast cancer and 128 healthy controls for single nucleotide polymorphisms (SNPs) rs2977537, rs2929970, rs2929973, rs2977530, and rs62514004, to determine whether these WNT1-inducible signaling pathway protein 1 (WISP-1) genetic polymorphisms increase the risk of developing breast cancer. Compared with wild-type (AA) carriers, those carrying the WISP1 rs62514004 AG or AG + GG genetic variants had a greater risk of developing breast cancer. In an evaluation of the association between clinicopathological aspects and the WISP1 SNP rs62514004 in the breast cancer cohort, patients with the GG genotype were less likely than those with the AA genotype to develop stage III/IV disease. Patients carrying the WISP1 rs2929973 GG + TT variant were almost twice as likely as those carrying the GT genotype to have estrogen receptor (ER)- and progesterone receptor (PR)-positive tumors, while those with the WISP1 rs62514004 AG + GG genetic variants were around twice as likely as those with the AA genotype to have HER2-positive tumors. This study details risk associations between WISP1 SNPs and breast cancer susceptibility in women of Han Chinese ethnicity.
    關聯: MEDICINE
    显示于类别:[醫學檢驗暨生物技術學系] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    index.html0KbHTML254检视/开启


    检视Licence

    在ASIAIR中所有的数据项都受到原著作权保护.

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈