ASIA unversity:Item 310904400/112847
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    题名: Bioactive peptides attenuate cardiac hypertrophy and fibrosis in spontaneously hypertensive rat hearts
    作者: 黃志揚;Huang, Chih-Yang;Srinivasan, N;Nithiyanantham, Srinivasan;Lia, Jia Ying;Liao, Jia Ying;Lin, Wan Teng;Lin, Wan Teng
    贡献者: 醫學檢驗暨生物技術學系
    关键词: Bioactive polypeptides;Fibrosis;Hypertrophy;SHR rats;Inflammation
    日期: 2019-11
    上传时间: 2020-09-01 05:57:36 (UTC+0)
    出版者: 亞洲大學
    摘要: Alcalase potato protein hydrolysate (APPH), a nutraceutical food, might an have important role in anti-obesity activity. Recent studies from our lab indicated that APPH treatment had lipolysis stimulating activity and identified was an efficient anti-obesity diet ingredient. In this study we aim to investigate the beneficial effects of pure peptide amino acid sequences (DIKTNKPVIF (DI) and IF) from APPH supplement in the regulation of cardiac hypertrophy and fibrosis on spontaneously hypertensive rats (SHR). We examined hematoxylin and eosin staining, Masson's trichrome staining, echocardiographic parameters, serum parameters, hypertrophy, inflammation and fibrotic marker expression to demonstrate efficacy of bioactive peptides in a SHR model. There was a significant upregulation between SHR and bioactive peptides treated groups in left heart weight (LHW), LHW/WHW, LHW/Tibia, LVIDd, and LVd mass. In addition, the bioactive peptides repress the protein expression of hypertrophy markers (BNP, MYH7), inflammation (TLR-4, p-NFkB, TNF-α, IL-6), and fibrotic markers (uPA, MMP-2, TIMP1, CTGF). In summary, these results indicate that DI and IF bioactive peptides from APPH attenuate cardiac hypertrophy, inflammation and fibrosis in the SHR model.
    關聯: JOURNAL OF FOOD AND DRUG ANALYSIS
    显示于类别:[醫學檢驗暨生物技術學系] 期刊論文

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