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| Title: | Deep sea minerals ameliorate diabetic-induced inflammation via inhibition of TNFα signaling pathways |
| Authors: | Chieh-Hsiang;Lu, Chieh-Hsiang;歐秀中;Ou, Hsiu-chung;Hsua, Cecilia;Day, Cecilia Hsuan;Chen, Hsiu-I;Chen, Hsiu-I;Pai, Pei-Ying;Pai, Pei-Ying;Lee, Cheng-Yu;Lee, Cheng-Yu;Che, Ray-Jade;Chen, Ray-Jade;Cha, Ruey-Lin;Chang, Ruey-Lin;Padma, Vijaya;PadmaViswanadha, Vijaya;Dennis, Jine-;Hsieh, Dennis Jine-Yuan |
| Contributors: | 醫學檢驗暨生物技術學系 |
| Date: | 2019-11 |
| Issue Date: | 2020-08-31 08:03:50 (UTC+0) |
| Publisher: | 亞洲大學 |
| Abstract: | It has been well-documented that the consumption of deep sea water (DSW) has beneficial effects on myocardial hypertrophy and cardiac apoptosis induced by hypercholesterolemia. However, the molecular mechanisms for the anti-inflammatory effects of DSW on diabetic cardiomyopathy are still largely unclear. The main purpose of this present study was to test the hypothesis that DSW exerts anti-inflammatory effects through the suppression of the TNF-α-mediated signaling pathways. IP injection of streptozotocin (STZ) at the dose of 65 mg/kg was used to establish a diabetes rat model. DSW mineral extracts that diluted in desalinated water were prepared in three different dosages and administered to the rats through gavages for 4 weeks. These dosages are DSW-1X (equivalent to 37 mg Mg2+ /kg/day), 2X (equivalent to 74 mg Mg2+ /kg/day) and 3X (equivalent to 111 mg Mg2+ mg/kg/day). Immunofluorescence staining and Western blot showed that the protein expression level of TNF-α was markedly higher in the STZ-induced diabetic rat hearts than in the control group. Consequently, the phosphorylation levels of the TNF-α-modulated downstream signaling molecules and P38 mitogen-activated protein kinases (MAPKs) were notably elevated in heart tissues of STZ-induced diabetes. These higher phosphorylation levels subsequently upregulated NF-κB-modulated inflammatory mediators, such as cyclooxygenase (COX)-II and inducible nitric oxide synthase (iNOS). However, treatment with DSW as well as MgSO4 , the main mineral in DSW, significantly reversed all the alterations. These findings suggest that DSW has potential as a therapeutic agent for preventing diabetes-related cardiovascular diseases. |
| Relation: | ENVIRONMENTAL TOXICOLOGY |
| Appears in Collections: | [醫學檢驗暨生物技術學系] 期刊論文
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