The Association of MMP-11 Promoter Polymorphisms With Susceptibility to Lung Cancer in Taiwan

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Title:	The Association of MMP-11 Promoter Polymorphisms With Susceptibility to Lung Cancer in Taiwan
Authors:	Guan-Liang, C;Chen, Guan-Liang;Shou-Cheng, W;Wang, Shou-Cheng;Hu, Wei-Chien;Huang, Wei-Chien;Cha, Wen-Shin;Chang, Wen-Shin;Tsa, Chia-Wen;Tsai, Chia-Wen;Li, Hsin-Ting;Li, Hsin-Ting;Shen, Te-Chun;Shen, Te-Chun;Hsia, Te-Chun;Hsia, Te-Chun;包大?;Bau, Da-Tian
Contributors:	生物資訊與醫學工程學系
Keywords:	Lung cancer genotype MMP-11 polymorphism Taiwan
Date:	2019-10
Issue Date:	2020-08-27 08:41:19 (UTC+0)
Publisher:	亞洲大學
Abstract:	Background/Aim: Matrix metalloproteinases-11 (MMP-11) overexpression has been reported in various types of cancer including lung cancer. We aimed to examine the contribution of MMP-11 genotypes to lung cancer risk. Materials and Methods: In this case-control study, the MMP-11 rs738791, rs2267029, rs738792 and rs28382575 genotypes were determined among 358 lung cancer patients and 716 age- and gender-matched healthy control Taiwanese. Results: The percentages of rs738791 CT and TT were 50.6% and 9.2% in the case group, slightly higher than 48.5% and 8.1% in the control group (p for trend=0.5638). The allelic analysis showed that the rs738791 T allele did not confer lung cancer risk compared with the C allele. Similarly, there was no association between rs2267029, rs738792 or rs28382575 and lung cancer risk. There was no joint effect of MMP-11 genotypes among ever smokers or non-smokers. Conclusion: The genotypes of MMP-11 play a minor role in determining lung cancer risk in Taiwan.
Relation:	ANTICANCER RESEARCH
Appears in Collections:	[生物資訊與醫學工程學系 ] 期刊論文

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