資料載入中.....
|
請使用永久網址來引用或連結此文件:
http://asiair.asia.edu.tw/ir/handle/310904400/112709
|
| 題名: | Protective effect of autologous transplantation of resveratrol preconditioned adipose-derived stem cells in the treatment of diabetic liver dysfunction in rat model |
| 作者: | Tung?Sheng, C;Chen, Tung?Sheng;Ju, Da?Tong;Cecilia?Hsua;Day, Cecilia?Hsuan;Yeh, Yu?Lan;Yeh, Yu?Lan;Che, Ray?Jade;Chen, Ray?Jade;Padma, Vijaya;Viswanadha, Vijaya Padma;Cha, Ruey?Lin;Chang, Ruey?Lin;Yuan?Chuan, L;Lin, Yuan?Chuan;Yao, Chun?Hsu;Yao, Chun?Hsu;黃志揚;Huang, Chih-Yang |
| 貢獻者: | 醫學檢驗暨生物技術學系 |
| 關鍵詞: | diabetes;liver dysfunction;mesenchymal stem cells;resveratrol. |
| 日期: | 2019-09 |
| 上傳時間: | 2020-08-20 07:12:33 (UTC+0) |
| 出版者: | 亞洲大學 |
| 摘要: | Previous studies stated that stem cell functions are reduced under high glucose environment, leading to reduce stem cell capability of tissue regeneration. This study aimed to investigate if stem cells preconditioned with resveratrol show better therapeutic effect on the treatment of liver dysfunction in diabetic rats than stem cells without resveratrol precondition. Male Wistar rats were divided into four groups including sham, DM (diabetic rats), DM + ADSC (DM rats receiving autologous transplantation of adipose-derived stem cells), and DM + pre-R-ADSC (DM rats receiving ADSC preconditioned with resveratrol). Compared with sham group, experimental results showed that DM group induced suppression of survival, suppression of Sirt1, activation of apoptotic, and activation of fibrotic pathways, leading to liver dysfunction. Autologous transplantation of ADSC (DM + ADSC) improved above pathways except for fibrotic signaling. By contrast, transplantation of resveratrol preconditioned ADSC (DM + pre-R-ADSC) significantly improved above pathways including fibrosis. Supplemental evidences suggest that resveratrol precondition increases ADSC viability under high glucose stress via Sirt1 and IGF1R expressions. Furthermore, increased secretion of IGF1 via paracrine route also confirmed in ADSC preconditioned with resveratrol. The experimental results imply that ADSC preconditioned with resveratrol shows potential in the treatment of liver dysfunction in DM patients with liver dysfunction. |
| 關聯: | Journal of Tissue Engineering and Regenerative Medicine |
| 顯示於類別: | [醫學檢驗暨生物技術學系] 期刊論文
|
文件中的檔案:
| 檔案 |
描述 |
大小 | 格式 | 瀏覽次數 |
|---|
| index.html | | 0Kb | HTML | 252 | 檢視/開啟 |
|
在ASIAIR中所有的資料項目都受到原著作權保護.
|
