Soya-cerebroside reduces IL-1β-induced MMP-1 production in chondrocytes and inhibits cartilage degradation: implications for the treatment of osteoarthritis

ASIA unversity > 醫學暨健康學院 > 生物科技學系 > 期刊論文 > Item 310904400/112422

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Title:	Soya-cerebroside reduces IL-1β-induced MMP-1 production in chondrocytes and inhibits cartilage degradation: implications for the treatment of osteoarthritis
Authors:	Liu, Shan-Chi;Liu, Shan-Chi;Tsa, Chun-Hao;Tsai, Chun-Hao;Wu, Tung-Ying;Wu, Tung-Ying;蔡長海;蔡輔仁;鍾景光;黃志揚;Huang;Chih-Yang;Yan, Jai-Sing;Yang, Jai-Sing;Hsu, Yuan-Man;Hsu, Yuan-Man;殷湄晶;Yin, Mei-chin;湯智昕;Chih-Hsin;Tang
Contributors:	生物科技學系
Date:	2019-05
Issue Date:	2019-11-08 03:45:53 (UTC+0)
Abstract:	Osteoarthritis (OA) commonly affects the synovial joint and is characterized by degradation of articular cartilage, which is largely mobilized by increased matrix metalloproteinase (MMP) activity. Soya-cerebroside, an extract of Cordyceps militaris, inhibits inflammatory cytokine production and monocyte migration in human synovial fibroblasts, although its effects are uncertain on MMP expression in chondrocytes and cartilage degradation. In this study, soya-cerebroside antagonized interleukin 1 beta (IL-1β)-induced MMP-1 production in chondrocytes, without cytotoxic effects. Functional genomic data confirm high levels of MMP-1 expression in OA tissue compared with normal tissue. Soya-cerebroside reduced MMP-1 expression via the focal adhesion kinase (FAK), mitogen-activated protein kinase (MEK), extracellular signal-regulated kinase (ERK) and AP-1 signalling pathways. In addition, soya-cerebroside suppressed IL-1β-promoted MMP-1 expression and cartilage degradation in animal models. Our report is the first to reveal that soya-cerebroside reduces MMP-1 production in chondrocytes and protects cartilage degradation through the FAK, MEK, ERK, and AP-1 signalling cascade.
Relation:	FOOD AND AGRICULTURAL IMMUNOLOGY
Appears in Collections:	[生物科技學系] 期刊論文

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