Bidirectional association between migraine and fibromyalgia: retrospective cohort analyses of two populations.

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Title:	Bidirectional association between migraine and fibromyalgia: retrospective cohort analyses of two populations.
Authors:	Penn, I-Wen;Penn, I-Wen;Chuang, Eric;Chuang, Eric;Chu, Tien-Yow;Chuang, Tien-Yow;Lin, Cheng-Li;Lin, Cheng-Li;高嘉鴻;Kao, Chia-Hung
Contributors:	生物資訊與醫學工程學系
Date:	2019-04
Issue Date:	2019-11-08 03:01:38 (UTC+0)
Abstract:	Objective Fibromyalgia (FM) and migraine are common pain disorders that tend to coexist. This study determined whether these two conditions exhibited any mutual influences. Setting Cohort study. Participants A retrospective, longitudinal cohort study was conducted using data obtained from a nationwide healthcare database. This study had two arms. Arm 1 comprised 33 216 patients with FM and arm 2 consisted of 7420 patients with migraine; all of these patients were diagnosed between 2000 and 2010. Using the aforementioned database, control subjects who had neither FM nor migraine and were matched with the FM and migraine patients by sex, age and index date of diagnosis were recruited. Each control cohort was four times the size of the corresponding study cohort. Follow-up for the control and study cohorts was conducted until the end of 2011. Results The incidence rates of FM and migraine were calculated in arms 1 and 2, respectively. The overall incidence of migraine was greater in the FM cohort than in the corresponding control cohort (4.39 vs 2.07 per 1000 person-years (PY)); crude HR=2.12, 95% CI=1.96 to 2.30; adjusted HR (aHR)=1.89, 95% CI=1.75 to 2.05). After adjustment for sex, age and comorbidities, the overall incidence of FM in the migraine cohort was 1.57 times greater than that in the corresponding control cohort (7.01 vs 4.49 per 1000 PY; aHR=1.52, 95% CI=1.39 to 1.65). Conclusions The present study revealed a bidirectional link between FM and migraine. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial.
Relation:	BMJ Open
Appears in Collections:	[Department of Biomedical informatics ] Journal Article

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