Association of Matrix Metallopeptidase-2 Promoter Polymorphisms With the Risk of Childhood Leukemia

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Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/112360

Title:	Association of Matrix Metallopeptidase-2 Promoter Polymorphisms With the Risk of Childhood Leukemia
Authors:	HSU, PEI-CHEN;HSU, PEI-CHEN;PE, JEN-SHENG;PEI, JEN-SHENG;CH, CHAO-CHUN;CHEN, CHAO-CHUN;CHA, WEN-SHIN;CHANG, WEN-SHIN;CHIEN-CHUNG;KUO, CHIEN-CHUNG;CH, SHUN-PING;CHENG, SHUN-PING;TSA, CHIA-WEN;TSAI, CHIA-WEN;包大?;Bau, Da-Tian;GONG, CHI-LI;GONG, CHI-LI
Contributors:	生物資訊與醫學工程學系
Date:	2019-03
Issue Date:	2019-11-08 02:18:34 (UTC+0)
Abstract:	The association of matrix metalloproteinase-2 (MMP-2) genotypes with adult leukemia has been reported only once, but never for childhood leukemia. This study aimed to determine the role of MMP-2 promoter -1306 (rs243865) and -735 (rs2285053) genotypes in childhood leukemia risk. MATERIALS AND METHODS: This case-control study included 266 patients and 266 age- and gender-matched healthy controls. The polymorphic sites of MMP-2 were genotyped by typical polymerase chain reaction-restriction fragment length polymorphism. RESULTS: The CC, CT and TT of rs243865 genotype were 75.2, 23.7 and 1.1% in the case group and 69.2, 28.9 and 1.9% in the control group, respectively. The CT and TT genotypes caused a 0.75- and 0.55-fold increase in the risk of childhood leukemia, respectively. There was no differential distribution of rs2285053 genotypes. Allelic frequency analysis showed that the T allele of MMP-2 promoter -1306 and -735 conferred lower susceptibility than the C allele. CONCLUSION: The MMP-2 promoter genotypes play a minor role in determining personal susceptibility to childhood leukemia among the Taiwanese. Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved. KEYWORDS: Childhood leukemia; MMP-2; Taiwan; genotype; polymorphism
Relation:	ANTICANCER RESEARCH
Appears in Collections:	[Department of Biomedical informatics ] Journal Article

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