Antibacterial activity of ovatodiolide isolated from Anisomeles indica against Helicobacter pylori

ASIA unversity > 醫學暨健康學院 > 健康產業管理學系 > 期刊論文 > Item 310904400/112086

jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://asiair.asia.edu.tw/ir/handle/310904400/112086

题名:	Antibacterial activity of ovatodiolide isolated from Anisomeles indica against Helicobacter pylori
作者:	Lie, Hsiu-Man;Lien, Hsiu-Man;Wu, Hui-Yu;Wu, Hui-Yu;Hu, Chiu-Lien;Hung, Chiu-Lien;Ch, Chih-Jung;Chen, Chih-Jung;Wu, Chia-Lin;Wu, Chia-Lin;賴志河;Lai, Chih-Ho
贡献者:	健康產業管理學系
日期:	2019-03
上传时间:	2019-09-18 03:40:00 (UTC+0)
摘要:	Helicobacter pylori infection is associated with high incidence of gastric diseases. The extensive therapy of H. pylori infection with antibiotics has increased its resistance rates worldwide. Ovatodiolide, a pure constituent isolated from Anisomeles indica, has been demonstrated to possess bactericidal activity against H. pylori. In this study, ovatodiolide inhibited the growth of both H. pylori reference strain and clinical multidrug-resistant isolates. Docking analysis revealed that ovatodiolide fits into the hydrophobic pocket of a ribosomal protein, RpsB. Furthermore, ovatodiolide inhibited bacterial growth by reducing levels of RpsB, which plays a crucial role in protein translation. Our results demonstrate that ovatodiolide binds to a ribosomal protein and interferes with protein synthesis. This study provides evidence that ovatodiolide has the potential to be developed into a potent therapeutic agent for treating H. pylori infection.
關聯:	Scientific Reports
显示于类别:	[健康產業管理學系] 期刊論文

文件中的档案:

档案	描述	大小	格式	浏览次数
index.html		0Kb	HTML	443	检视/开启

检视Licence

在ASIAIR中所有的数据项都受到原著作权保护.