Enhanced Cell Response to Zirconia Surface Immobilized with Type I Collagen

ASIA unversity > 資訊學院 > 生物資訊與醫學工程學系 > 期刊論文 > Item 310904400/112064

jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://asiair.asia.edu.tw/ir/handle/310904400/112064

题名:	Enhanced Cell Response to Zirconia Surface Immobilized with Type I Collagen
作者:	Hs, Chun-Miao;Hsu, Chun-Miao;Sun, Ying-Sui;Sun, Ying-Sui;黃何雄;Huang, Her-Hsiung
贡献者:	生物資訊與醫學工程學系
日期:	2019-02
上传时间:	2019-09-18 03:09:26 (UTC+0)
摘要:	Zirconia (ZrO2) dental implants provide good biocompatibility, have good corrosion resistance, and have a color that is similar to that of natural teeth. Unfortunately, ZrO2 is a bioinert material and therefore achieves osseointegration difficultly. In this study, we sought to enhance osseointegration by producing rough ZrO2 surfaces that contain hydroxyl groups (designated ZSA) through the use of sandblasting in conjunction with alkaline treatment. We immobilized type I collagen on ZSA surfaces using the natural cross-linker, procyanidin. Our results further showed that surfaces produced in ZSA-P/C featured more and steadier type I collagen than surfaces produced in ZSA-C. The ZSA-P/C also presented superior cell responses in terms of adhesion, proliferation, and mineralization of human bone marrow mesenchymal stem cells. The enhanced cell responses in the ZSA-P/C were induced through the prolonged activation of focal adhesion kinase, AKT (the phosphoinositide 3-kinase pathway), and p38 (the mitogen-activated protein kinase pathway). The simple and novel approach to immobilize type I collagen on roughened ZrO2 surfaces presented in this article can likely benefit dental implant applications.
關聯:	JOURNAL OF DENTAL RESEARCH
显示于类别:	[生物資訊與醫學工程學系 ] 期刊論文

文件中的档案:

没有与此文件相关的档案.

检视Licence

在ASIAIR中所有的数据项都受到原著作权保护.

数据加载中.....