Exercise training augments Sirt1-signaling and attenuates cardiac inflammation in D-galactose induced-aging rats

ASIA unversity > 醫學暨健康學院 > 生物科技學系 > 期刊論文 > Item 310904400/111960

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Title:	Exercise training augments Sirt1-signaling and attenuates cardiac inflammation in D-galactose induced-aging rats
Authors:	Che, Wei?Kung;Chen, Wei?Kung;Tsa, Ying?Lan;Tsai, Ying?Lan;徐布;Shibu, Marthandam Asokan;She, Chia?Yao;Shen, Chia?Yao;張李淑女;Lee, Shu-Nu Chang;Che, Ray?Jade;Chen, Ray?Jade;Yao, Chun?Hsu;Yao, Chun?Hsu;Ban, Bo;Ban, Bo;郭薇雯;Kuo, Wei?Wen;黃志揚;Huang;Chih-Yang
Contributors:	生物科技學系
Date:	2018-12
Issue Date:	2019-09-10 05:19:26 (UTC+0)
Abstract:	Exercise is known to be beneficial in controlling aging associated disorders however, the consequence of long-term exercise on cardiac health among aging population is not much clear. In this study the protective effect of exercise on aging associated cardiac disorders was determined using a D-galactose-induced aging model. Eight weeks old Sprague Dawley rats were given intraperitoneal injection of 150 mL/kg D-galactose. Swimming exercise was provided in warm water for 60 min/day for five days per week. Hematoxylin and eosin staining of cardiac tissue sections revealed cardiomyocyte disarrangements in the aging rat hearts but long-term exercise training showed improvements in the cardiac histology. Exercise training also enhanced the expression levels of proteins such as SIRT1, PGC-1α and AMPKα1 that are associated with energy homeostasis and further suppressed aging associated inflammatory cytokines. Our results show that long-term exercise training potentially enhances SIRT1 associated anti-aging signaling and provide cardio-protection against aging. Keywords: senescence, longevity, inflammation, swimming
Relation:	Aging-US
Appears in Collections:	[生物科技學系] 期刊論文

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