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http://asiair.asia.edu.tw/ir/handle/310904400/111562
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| Title: | The Association of Matrix Metalloproteinase-1 Promoter Polymorphisms with Breast Cancer |
| Authors: | Hs, Chieh-Lun;Hsiao, Chieh-Lun;Liang-Chih, Liang-Chih L;Liu, Liang-Chih;Sh, Tzu-Ching;Shih, Tzu-Ching;Lai, Yi-Liang;Lai, Yi-Liang;Hsu, Shih-Wei;Hsu, Shih-Wei;Hwei-Chung, W;Wang, Hwei-Chung;Pan, Su-Yi;Pan, Su-Yi;Shen, Te-Chun;Shen, Te-Chun;Tsa, Chia-Wen;Tsai, Chia-Wen;Cha, Wen-Shin;Chang, Wen-Shin;Chen-Hsien, S;Su, Chen-Hsien;Wa, Tzong-Der;Way, Tzong-Der;Ch, Jing-Gung;Chung, Jing-Gung;包大?;Bau, Da-Tian;* |
| Contributors: | 生物資訊與醫學工程學系 |
| Keywords: | Breast cancer, genotype, MMP-1, polymorphism, Taiwan |
| Date: | 2018-05 |
| Issue Date: | 2018-10-22 03:28:13 (UTC+0) |
| Abstract: | Background/Aim: The family of matrix metalloproteinases (MMPs) are responsible for the homeostasis of extracellular matrix components and their genetic polymorphisms may be associated with cancer susceptibility. The serum levels of MMP-1 have been reported to be lower in breast cancer patients than healthy subjects. In the current study, we aimed at investigating the contribution of a polymorphism in the promoter region of MMP-1 to breast cancer in Taiwan. Materials and Methods: The MMP-1 rs1799705 polymorphic genotypes were genotyped among 1,232 breast cancer patients and 1,232 healthy controls by the typical polymerase chain reaction-restriction fragment length polymorphism methodology. Results: The percentages of 2G/2G, 1G/2G, and 1G/1G for MMP1 -1607 genotypes were 35.4, 40.6 and 24.0% in the breast cancer group and 34.1, 43.6, and 22.3% in the healthy control group (p trend=0.3025), respectively. The odds ratios (ORs) after adjusting for age, smoking and alcohol drinking status for those carrying 1G/2G and 1G/1G genotypes at MMP1 -1607 were 0.93 (95%CI=0.76-1.11, p=0.2390) and 1.01 (95%CI=0.77-1.23, p=0.7377), respectively, compared to those carrying the wild-type 2G/2G genotype. Supporting this finding, the adjusted OR for those carrying the 1G allele at MMP-1 -1607 was 1.03 (95%CI=0.91-1.18, p=0.8860), compared to those carrying the wild-type 2G allele. Our findings suggest that the polymorphic genotypes at MMP1 promoter -1607 investigated in the current study, may not play a major role in determining cancer susceptibility to breast cancer in Taiwan. Other early diagnostic and predictive markers are urgently needed for personalized and precise breast cancer detection and therapy. |
| Relation: | IN VIVO |
| Appears in Collections: | [生物資訊與醫學工程學系 ] 期刊論文
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