A unique hybrid-structured surface produced by rapid electrochemical anodization enhances bio-corrosionresistance and bone cell responses of β-type Ti-24Nb-4Zr-8Sn alloy

ASIA unversity > 資訊學院 > 生物資訊與醫學工程學系 > 期刊論文 > Item 310904400/111558

Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/111558

Title:	A unique hybrid-structured surface produced by rapid electrochemical anodization enhances bio-corrosionresistance and bone cell responses of β-type Ti-24Nb-4Zr-8Sn alloy
Authors:	Liu, Chia-Fei;Lee, Tzu-Hsin;Lee, Tzu-Hsin;Liu, Jeng-Fen;Liu, Jeng-Fen;Hou, Wen-Tao;Hou, Wen-Tao;Li, Shu-Jun;Li, Shu-Jun;Hao, Yu-Lin;Hao, Yu-Lin;Pan, Haobo;Pan, Haobo;黃何雄;Huang, Her-Hsiung;*
Contributors:	生物資訊與醫學工程學系
Date:	2018-04
Issue Date:	2018-10-22 03:27:56 (UTC+0)
Abstract:	Ti-24Nb-4Zr-8Sn (Ti2448), a new β-type Ti alloy, consists of nontoxic elements and exhibits a low uniaxial tensile elastic modulus of approximately 45 GPa for biomedical implant applications. Nevertheless, the bio-corrosion resistance and biocompatibility of Ti2448 alloys must be improved for long-term clinical use. In this study, a rapid electrochemical anodization treatment was used on Ti2448 alloys to enhance the bio-corrosion resistance and bone cell responses by altering the surface characteristics. The proposed anodization process produces a unique hybrid oxide layer (thickness 50–120 nm) comprising a mesoporous outer section and a dense inner section. Experiment results show that the dense inner section enhances the bio-corrosion resistance. Moreover, the mesoporous surface topography, which is on a similar scale as various biological species, improves the wettability, protein adsorption, focal adhesion complex formation and bone cell differentiation. Outside-in signals can be triggered through the interaction of integrins with the mesoporous topography to form the focal adhesion complex and to further induce osteogenic differentiation pathway. These results demonstrate that the proposed electrochemical anodization process for Ti2448 alloys with a low uniaxial tensile elastic modulus has the potential for biomedical implant applications.
Relation:	Scientific Reports
Appears in Collections:	[生物資訊與醫學工程學系 ] 期刊論文

Files in This Item:

File	Size	Format
index.html	0Kb	HTML	430	View/Open

Loading...