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http://asiair.asia.edu.tw/ir/handle/310904400/111544
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| Title: | Impact of matrix metalloproteinase-11 gene polymorphisms upon the development and progression of hepatocellular carcinoma |
| Authors: | Wang, Bin;Wang, Bin;Hs, Chin-Jung;Hsu, Chin-Jung;Hsiang-Lin, Lin L;Lee, Hsiang-Lin;Chia-Hsuan, Chia-Hsuan C;Chou, Chia-Hsuan;Su, Chen-Ming;Su, Chen-Ming;Yang, Shun-Fa;Yang, Shun-Fa;湯智昕;Chih-Hsin, Tang;* |
| Contributors: | 生物科技學系 |
| Keywords: | MMP-11 polymorphisms, Hepatocellular carcinoma, Single nucleotide polymorphism, Susceptibility |
| Date: | 2018-04 |
| Issue Date: | 2018-10-22 03:25:46 (UTC+0) |
| Abstract: | Hepatocellular carcinoma (HCC) is a liver malignancy and a major cause of cancer mortality worldwide. Matrix metalloproteinase-11 (MMP-11), also known as stromelysin-3, plays a critical role during tumor migration, invasion and metastasis. Here, we report on the association between five single nucleotide polymorphisms (SNPs) - rs738791, rs2267029, rs738792, rs28382575, and rs131451 - of the MMP-11 gene and HCC susceptibility, as well as clinical outcomes, in 293 patients with HCC and in 586 cancer-free controls. We found that carriers of the CT+TT allele of the rs738791 variant were at greater risk of HCC compared with wild-type (CC) carriers. Moreover, carriers of at least one C allele (C/T+C/C genotype) at the MMP-11 SNP rs738792 were likely to progress to Child-Pugh B or C grade, while individuals with at least one C allele (C/T+C/C genotype) at the MMP-11 SNP rs28382575 were at higher risk of developing stage III/IV disease, large tumors or lymph node metastasis. We believe that genetic variations in the MMP-11 gene may help to predict early-stage HCC and act as reliable biomarkers for HCC progression. |
| Relation: | International Journal of Medical Sciences |
| Appears in Collections: | [生物科技學系] 期刊論文
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