Allergic Conjunctivitis-induced Retinal Inflammation Promotes Myopia Progression

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Title:	Allergic Conjunctivitis-induced Retinal Inflammation Promotes Myopia Progression
Authors:	魏長菁;Wei, Chang-Ching;萬磊*
Contributors:	生物科技學系
Date:	2018-01
Issue Date:	2018-08-20 01:44:28 (UTC+0)
Abstract:	Myopia is a highly prevalent eye disease. There is limited information suggesting a relationship between myopia and inflammation. We found children with allergic conjunctivitis (AC) had the highest adjusted odds ratio (1.75, 95% confidence interval [CI], 1.72–1.77) for myopia among the four allergic diseases. A cohort study was conducted and confirmed that children with AC had a higher incidence and subsequent risk of myopia (hazard ratio 2.35, 95%CI 2.29–2.40) compared to those without AC. Lower refractive error and longer axial length were observed in an AC animal model. Myopia progression was enhanced by tumor necrosis factor (TNF)-α or interleukin (IL)-6 administration, two cytokines secreted by mast cell degranulation. The TNF-α or IL-6 weakened the tight junction formed by corneal epithelial (CEP) cells and inflammatory cytokines across the layer of CEP cells, which increased the levels of TNF-α, IL-6, and IL-8 secreted by retinal pigment epithelial cells. The expression levels of TNF-α, IL-6, IL-8, monocyte chemoattractant protein-1, and nuclear factor kappa B were up-regulated in eyes with AC, whereas IL-10 and the inhibitor of kappa B were down-regulated. In conclusion, the experimental findings in mice corroborate the epidemiological data showing that allergic inflammation influences the development of myopia. Keywords: Myopia, Inflammation, Asthma, Atopic dermatitis, Allergic rhinitis, Allergic conjunctivitis, Population-based study
Relation:	EBioMedicine
Appears in Collections:	[Department of Biotechnology] Journal Article

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