ASIA unversity:Item 310904400/111348
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 94286/110023 (86%)
造訪人次 : 21718505      線上人數 : 443
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋


    請使用永久網址來引用或連結此文件: http://asiair.asia.edu.tw/ir/handle/310904400/111348


    題名: Differential Characterization of Temozolomide-Resistant Human Glioma Cells.
    作者: La, Sheng-Wei;Lai, Sheng-Wei;Huan, Bor-Ren;Huang, Bor-Ren;Liu, Yu-Shu;Liu, Yu-Shu;Li, Hsiao-Yun;Lin, Hsiao-Yun;Chun-Chuan, Chun-Chuan C;Chen, Chun-Chuan;蔡政芳;Tsai, Cheng-Fang;盧大宇;Lu, Dah-Yuu;*;Lin, Chingju;Lin, Chingju
    貢獻者: 生物科技學系
    日期: 2018-01
    上傳時間: 2018-08-20 01:44:00 (UTC+0)
    摘要: Glioblastoma multiforme (GBM) is the most common type of primary and malignant tumor occurring in the adult central nervous system. Temozolomide (TMZ) has been considered to be one of the most effective chemotherapeutic agents to prolong the survival of patients with glioblastoma. Many glioma cells develop drug-resistance against TMZ that is mediated by increasing O-6-methylguanine-DNA methyltransferase (MGMT) levels. The expression of connexin 43 was increased in the resistant U251 subline compared with the parental U251 cells. The expression of epithelial–mesenchymal transition (EMT)-associated regulators, including vimentin, N-cadherin, and β-catenin, was reduced in the resistant U251 subline. In addition, the resistant U251 subline exhibited decreased cell migratory activity and monocyte adhesion ability compared to the parental U251 cells. Furthermore, the resistant U251 subline also expressed lower levels of vascular cell adhesion molecule (VCAM)-1 after treatment with recombinant tumor necrosis factor (TNF)-α. These findings suggest differential characteristics in the drug-resistant GBM from the parental glioma cells.

    Keywords: glioblastoma, temozolomide, connexin 43, drug-resistant
    關聯: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
    顯示於類別:[生物科技學系] 期刊論文

    文件中的檔案:

    檔案 大小格式瀏覽次數
    index.html0KbHTML363檢視/開啟


    在ASIAIR中所有的資料項目都受到原著作權保護.

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋