以健保資料庫分析台灣地區肝癌疾病與高血壓用藥之相關性探討

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题名:	以健保資料庫分析台灣地區肝癌疾病與高血壓用藥之相關性探討
作者:	陳思彤
贡献者:	生物資訊與醫學工程學系碩士在職專班
关键词:	肝癌、高血壓、高血脂、糖尿病、高血壓控制用藥、liver cancer、hypertension、hyperlipidemia、diabetes、hypertension medication
日期:	2018
上传时间:	2018-06-21 02:14:59 (UTC+0)
出版者:	亞洲大學
摘要:	本研究目的為分析台灣地區肝癌病患的發生率及分佈情形，探討高血壓、高血脂、糖尿病、B型肝炎及C型肝炎此五項危險因子相關疾病與肝癌的關係分析研究，並且試圖對高血壓患者全民健保給付常用藥的使用者性別及累積用藥量多寡探討其與罹患肝癌之間的相關性及差異性。本研究以台灣全民健保資料庫為資料來源，利用國人門診資料找出肝癌患者，並將高血壓、高血脂、糖尿病、B型肝炎及C型肝炎與肝癌疾病串檔結合，再用統計方法計算出肝癌患者與高血壓、高血脂、糖尿病、B型肝炎及C型肝炎各別的相關係數。以2004~2013年台灣全民健保資料庫的資料庫，做為肝癌患者研究樣本，統計研究十年期間肝癌患者與高血壓、高血脂、糖尿病、B型肝炎及C型肝炎的相關性及差異性。研究結果呈現出，高齡及女性為肝癌高風險群；女性罹患高血壓後藥物用量稍較男性藥物用量高；使用血壓控制藥物的累積用量與有無肝癌也具有相關性。為何女性罹高血壓症狀較嚴重以及高血壓與有無肝癌間的相關病理機轉都值得再加以深入研究。 The aim of this study is to investigate and analyze the relevance and distribution of liver cancer in Taiwan, and to explore the relationship among the five dangerous factors such as hypertension, hyperlipidemia, diabetes, Hepatitis B and Hepatitis C. Secondly, we are also interested in the relationship between hypertension medication and liver cancer. Is there any effects from hypertension medication to reducing liver cancer? The data came from the Taiwan National Health Insurance Database. As a social welfare, the National Health Insurance almost recorded all citizen’s medical history. Use of the data to identify liver cancer patients and string together the hypertension, hyperlipidemia, diabetes, hepatitis B and hepatitis C patients’ data. Then, use of statistical methods to calculate the liver cancer patients with hypertension, hyperlipidemia, diabetes, hepatitis B and hepatitis C separately. Based on the data of Taiwan's National Health Insurance Database from 2004 to 2013 as the studied sample, calculate statistically for the risk relationship between the liver cancer patients and patients with hypertension, hyperlipidemia, diabetes, Hepatitis B and Hepatitis C. In summary, the high risk of target groups are the elders and female. Also, female hypertension patients took higher does than male patients to control blood pressure. Last, cumulative usage of hypertension medicine is relevant with liver cancer.
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