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| Title: | Preventive Effects of Ophiocordyceps sinensis Mycelium on High-Fat Diet Induced Lipid Dysregulation and Hepatic Inflammation of Mice |
| Authors: | Ch, Chung-Hsi;Chou, Chung-Hsi;林惠雯;Lin, Hui-Wen;Sa, Yi-Hsieng;Wu, Yi-Hsieng Samuel;Ch, Chia-Chun;Chiang6, Chia-Chun;Fu, Shih-Guei;Chen, Yi-Chen |
| Contributors: | 視光學系 |
| Date: | 2017-11 |
| Issue Date: | 2018-04-03 01:44:27 (UTC+0) |
| Abstract: | Recently, pathological changes that threat the public wellness in the modern society may relate to the westernized lifestyle, nutritional imbalance and so on. Consequently, a high prevalence of metabolic syndromes, i.e. hyperlipidemia, fatty liver, diabetes, cardiovascular diseases, results in a major problem globally. According to a statistical data from World Health Organization 1, more than 10% of the adults are obese in the world. Meanwhile, lipid dysregulation and obesity has been regarded as major factors enhancing the mortality on the human clinical research. It also occurs in Taiwan, where there are more than 51.5% male and 32.6% female obese or overweight, respectively 2.
Ophiocordyceps sinensis (OS, renamed from Cordyceps sinensis in 2007), regarded as a traditional tonic food supplementation, is usually found in elevation of 3000 to 5000 meters of mountains in southwest of China. It is rare and precious due to its slow generation time and its bioacive benefits in the oriental society. An ancient Chinese medical book, Compendium of Materia and Medic, revealed its therapeutic functions, which inspire scientists’ studies. Due to the rareness of OS, Ophiocordyceps sinensis mycelium (OSM) has become another major subject in following investigations. Based on previous studies, the bioactivities of OS and OSM were found as immunomodulation 3, anti-inflammation 4, anti-tumor 5, antioxidation 6, cardiovascular-protection 6, anti-fibrosis 7, and regulating male reproductive function 8. Besides, the evidences for exercise-endurance promotion and anti-fatigue activities of OS were demonstrated, and it meditated upregulation of some metabolic regulators, such as AMP-activated protein kinase (AMPK), peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1), and peroxisome proliferator activated receptor (PPAR), in the skeletal muscle 9. Recently, it was reported that cordycepin, one nucleotide derivatives in OS, could activate AMPK in HepG2 cells and then decrease intracellular lipid accumulation 10. These evidences showed that OS or OSM would affect lipid metabolism in vitro. Briefly, OS-origin materials have shown its potential of medical and nutraceutical candidates; hence, the aim of the present study was to investigate the alleviative effects of OSM on the development of dyslipidemic diseases by a high-fat diet (HFD) induced mouse model. |
| Relation: | Journal of Food and Nutrition Research |
| Appears in Collections: | [視光學系] 期刊論文
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