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    Title: Effect of Long-term Incretin-Based Therapies on Ischemic Heart Diseases in Patients with Type 2 Diabetes Mellitus: A Network Meta-analysis
    Authors: Chou, Che-Yi;Cha, Ying-Tzu;Chang, Ying-Tzu;Yan, Jia-Lian;Yang, Jia-Lian;Wang, Jiun-Yi;李翠娥;Li, Cui-Er;Wang, Ruey-Y;Wang, Ruey-Yun;Hung, Chin-C;Hung, Chin-Chuan
    Contributors: 體育室
    Date: 2017-11
    Issue Date: 2018-04-03 01:41:31 (UTC+0)
    Abstract: Patients with type 2 diabetes mellitus (T2DM) experience many cardiovascular complications. Several studies have demonstrated the cardioprotective effects of incretin-based therapies; however, there are few studies on the effects of long-term incretin-based therapies on cardiovascular events. Therefore, the present study conducted a systematic review and network meta-analysis to evaluate the effects of long-term incretin-based therapies on ischaemic diseases. We searched PubMed, CENTRAL, and Clinicaltrial.gov to retrieve randomised control trials reported until December 2016 and enrolled only RCTs with more than a 1-year follow-up. The network meta-analysis was performed using R Software with a GeMTC package. A total of 40 trials were included. Dipeptidyl peptidase 4 inhibitors and glucagon-like peptide-1 agonists were associated with a lower risk of myocardial infarction (MI) than were sulfonylureas (odds ratio [95% credible interval] 0.41 [0.24–0.71] and 0.48 [0.27–0.91], respectively). These results suggested that patients with T2DM receiving long-term incretin-based therapies have a lower risk of MI than do those receiving sulfonylurea-based therapy. These findings highlight the risks of cardiovascular events in patients who receive long-term incretin-based therapies, and may provide evidence for the selection of antidiabetic therapy in the future.
    Relation: Scientific Reports
    Appears in Collections:[Office of Physical Education] Journal Article

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