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http://asiair.asia.edu.tw/ir/handle/310904400/110749
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| Title: | The Association of Flap Endonuclease 1 Genotypes with the Susceptibility of Endometriosis |
| Authors: | 周安國;Chou, An-Kuo;Shen, Ming-Yi;Chen, Fang-Yu;Hs, Chieh-Lun;Hsiao, Chieh-Lun;Liang-Chun, S;Shih, Liang-Chun;Cha, Wen-Shin;Chang, Wen-Shin;Tsa, Chia-Wen;Tsai, Chia-Wen;Yin, Tsung-Ho;Ying, Tsung-Ho;Ming-Hsien, W;Wu, Ming-Hsien;Hua, Chung-Yu;Huang, Chung-Yu;包大?;Bau, Da-Tian |
| Contributors: | 生物資訊與醫學工程學系 |
| Date: | 2017-11 |
| Issue Date: | 2018-04-03 01:16:18 (UTC+0) |
| Abstract: | Background/Aim: Flap endonuclease 1 (FEN1),
a protein with multiple functions in genome stability
maintenance, is important in cancer prevention. The two
functional germline variants of FEN1, rs174538 and
rs4246215, regarding cancer susceptibility have been
reported in lung, breast, liver, esophageal, gastric, colorectal
cancer, glioma and leukemia, but not endometriosis. In this
study, we firstly aimed at evaluating the contribution of
FEN1 genotypes to endometriosis risk in a representative
Taiwan population. Materials and Methods: In total, 153
patients with endometriosis and 636 non-cancer healthy
controls were genotyped by polymerase chain reactionrestriction
fragment length polymorphism (PCR-RFLP)
methodology. Results: The genotypes of FEN1 rs174538, but
not those of rs4246215, were differently distributed between
the endometriosis and control groups. In detail, the AA of
FEN1 rs174538 genotypes were significantly less frequently
found among endometriosis patients than among controls
(odds ratio [OR]=0.43, 95% confidence interval [CI]=0.24-
0.78, p=0.0125). The A allele at FEN1 rs174538 was also
significantly less frequent among cases than controls
(OR=0.65, 95%CI=0.50-0.86, p=0.0021). As for age of first
menarche, those with first menarche at the age >12.8
carrying the FEN1 rs174538 AA genotype conferred lower
OR of 0.29 (95%CI=0.11-0.78, p=0.0381) for endometriosis.
Regarding the full pregnancy status, those without having
had a full-term pregnancy carrying the FEN1 rs174538 AA
genotype were of lower risk (ORs=0.12, 95%CI=0.03-0.53,
p=0.0050). Conclusion: The FEN1 rs174538 A allele is a
novel protective biomarker for endometriosis and this
genotype may have interactions with age- and hormonerelated
factors on the development of endometriosis. |
| Relation: | Cancer Genomics & Proteomics |
| Appears in Collections: | [生物資訊與醫學工程學系 ] 期刊論文
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