Tissue Engineered Cartilage Constructs for Cartilage Regeneration

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题名:	Tissue Engineered Cartilage Constructs for Cartilage Regeneration
作者:	Alv, Kai-Xing;Lee, Kai-Xing Alvin;Ng, Hooi Yee;沈育芳;Shen, Yu-Fang
贡献者:	生物資訊與醫學工程學系
日期:	2017-10
上传时间:	2018-04-03 01:15:20 (UTC+0)
摘要:	Cartilage is a unique tissue with structures specifically designed for its intended functions. It is a vascular, aneural and alymphatics, thus severely limiting its self repairing capabilities. Current treatment options are insufficient in treatment of cartilage diseases. Therefore, researchers are exploring the use of tissue engineered cartilage constructs to treat cartilage diseases and for cartilage regeneration. However, a good cartilage construct should have some prerequisite requirements, and physical architectures such as pore size, distribution, geometry, pore interconnectivity and porosity can determine feasibility of construct. In addition, advancement in biomaterials development and biofabrication techniques have enabled biofabrication of more complex constructs that are able to better mimic native cartilages. Current ideal physical architectures of cartilage constructs, commonly used biomaterials and synthetic materials and several biofabrication techniques are reviewed in this review. In addition, current problems faced in cartilage biofabricated are also highlighted in this review.
關聯:	JSM Bone and Joint Diseases
显示于类别:	[生物資訊與醫學工程學系 ] 期刊論文

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