Improved final predicted height with the injection of leuprolide in children with earlier puberty: A retrospective cohort study

ASIA unversity > 醫學暨健康學院 > 生物科技學系 > 期刊論文 > Item 310904400/110728

請使用永久網址來引用或連結此文件: http://asiair.asia.edu.tw/ir/handle/310904400/110728

題名:	Improved final predicted height with the injection of leuprolide in children with earlier puberty: A retrospective cohort study
作者:	林怡君;Lin, Yi-Chun;林知瑩;Lin, Chih-Ying;謝秀盈;Chee, Siew-Yin;顏宏融;Yen, Hung-Rong;蔡輔仁;Tsai, Fuu-Jen;陳秋瑩;Chen, Chiu-Ying;王仲興;Wang, Chung-Hsing
貢獻者:	生物科技學系
日期:	2017-10
上傳時間:	2018-04-03 01:14:43 (UTC+0)
摘要:	The adult height of children with early onset puberty is limited by the premature maturation of hypothalamic-pituitary-gonadal axis. To evaluate the effects of gonadotropin-releasing hormone analog (GnRHa) treatment on the final height (FH) and bone maturation rate (BMR) in girls with early puberty (EP) or idiopathic central precocious puberty (ICPP), we examined data from girls who were diagnosed with EP or ICPP and underwent GnRHa (Leuplin Depot: 3.75 mg/month) at China Medical University Hospital, in Taiwan, between 2006 and 2015. Patients were observed until the achievement of FH and divided into an “EP group” (T-ep) and “ICPP group” (T-icpp) according to the age of onset of puberty. Eighty-seven patients were enrolled (T-ep, N = 44, puberty onset at 8–10 years; T-icpp, N = 43, puberty onset before 8 years). The demographic data of girls with EP or IPP was characterized. BMR, change in predicted final height (PFH) after GnRHa treatment, target height (TH) and FH were measured. After GnRHa treatment, the study groups (T-ep: 160.24±6.18 cm, T-icpp: 158.99±5.92 cm) both had higher PFH than at initiation (T-ep: 159.83±7.19 cm, T-icpp: 158.58±5.93 cm). There was deceleration of BMR in both groups (T-ep: 0.57±0.39; T-icpp: 0.97±0.97) and a significant difference between the groups (p = 0.027). The gap in FH standard deviation scores (SDS) and TH SDS had a significant difference in T-ep (p = 0.045) but not in T-icpp. Moreover, there was no difference in the gap of PFH SDS between the 1st and final treatment in both groups. We concluded that GnRHa decelerated BMR in girls with earlier puberty. Further prospective clinical studies are warranted.
關聯:	PLoS One.
顯示於類別:	[生物科技學系] 期刊論文

文件中的檔案:

檔案	大小	格式	瀏覽次數
index.html	0Kb	HTML	454	檢視/開啟

在ASIAIR中所有的資料項目都受到原著作權保護.

資料載入中.....