Effects of Wild Bitter Gourd Treatment on Endotoxin-induced Sepsis Inflammatory Responses

ASIA unversity > 醫學暨健康學院 > 食品營養與保健生技學系 > 博碩士論文 > Item 310904400/10933

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題名:	Effects of Wild Bitter Gourd Treatment on Endotoxin-induced Sepsis Inflammatory Responses
作者:	SHUO-YU CIOU
貢獻者:	Department of Health and Nutrition Biotechnology
關鍵詞:	Wild bitter gourd;Sepsis;Anti-inflammatory effects;PPARγ
日期:	2010
上傳時間:	2010-11-08 03:34:17 (UTC+0)
出版者:	Asia University
摘要:	A wild species of Momordica charantia, wild bitter gourd (Momordica charantia Linn.var. abbreviata ser., or WBG), is native to tropical areas of Asia. A recent study showed that the ethyl acetate extract of WBG significantly activates PPARα and PPARγ in vitro. It was also shown to have a lipids-lowering and anti-diabetic effects in vitro. This study was designed to investigate the effects of WBG supplement on biochemical parameters and inflammatory-related mediators in septic mice. All Balb/c mice were classified into six groups as follows: normal group (N), sepsis group (S), positive control group (P), and WBG supplement sepsis groups (L, M, H). The results of the study demonstrated that WBG supplement sepsis groups its serum and liver lipid concentrations (triglyceride,cholesterol and non-esterified fatty acids) were significantly lower than sepsis group. As well as prevents liver fat accumulation and body weight gain associated with sepsis. Besides, the inflammatory-related mediators such as GOT, GPT,creatinine, C-RP, NO2 were also lower than sepsis group. Significantly inhibited the elevation of serum and spleen cytokines (IL-1, IL-6 and TNF-α) concentrations in WBG supplement sepsis groups especially in 10% (H) group. As a result of PPARγ activation lead to reducing the NF-B, iNOS and COX-2 protein expression. These results suggest that WBG supplement is beneficial for reducing LPS-induced sepsis resulted from its anti-inflammatory and lipids-lowering effects by modulating PPARα and PPARγactivation.
顯示於類別:	[食品營養與保健生技學系] 博碩士論文

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