A wild species of Momordica charantia, wild bitter gourd (Momordica charantia Linn.var. abbreviata ser., or WBG), is native to tropical areas of Asia. A recent study showed that the ethyl acetate extract of WBG significantly activates PPARα and PPARγ in vitro. It was also shown to have a lipids-lowering and anti-diabetic effects in vitro. This study was designed to investigate the effects of WBG supplement on biochemical parameters and inflammatory-related mediators in septic mice. All Balb/c mice were classified into six groups as follows: normal group (N), sepsis group (S), positive control group (P), and WBG supplement sepsis groups (L, M, H). The results of the study demonstrated that WBG supplement sepsis groups its serum and liver lipid concentrations (triglyceride,cholesterol and non-esterified fatty acids) were significantly lower than sepsis group. As well as prevents liver fat accumulation and body weight gain associated with sepsis. Besides, the inflammatory-related mediators such as GOT, GPT,creatinine, C-RP, NO2 were also lower than sepsis group. Significantly inhibited the elevation of serum and spleen cytokines (IL-1, IL-6 and TNF-α) concentrations in WBG supplement sepsis groups especially in 10% (H) group. As a result of PPARγ activation lead to reducing the NF-B, iNOS and COX-2 protein expression. These results suggest that WBG supplement is beneficial for reducing LPS-induced sepsis resulted from its anti-inflammatory and lipids-lowering effects by modulating PPARα and PPARγactivation.
