Diabetes affects the health conditions of at least 200 million people worldwide, and one person died from diabetes every 10 second around the world; IDF expects that by 2025, the death will increase to 3300 million.In Taiwan, the cause of death statistics announced by the Department of Health, Taiwan in year 98, showed that the diabetic has become the fifth leading cause of death, and accounted for 5.8% of overall mortality (Taiwan Department of Health, 2009); diabetes have become one of chronic diseases so that the bad control of diabetes would cause many complications. The latest two oral hypoglycemic medicines (Dipeptidyl Peptidase-IV Inhibitor) introduced into Taiwan, the pyrrolidine derivatives, can inhibit the activity of DPP IV, avoid endogenous GLP-1 (glucagon-likepeptide-1), and the breakdown of GIP (glucose-dependent insulinotropic polypeptide) to reduce high blood sugar, not to affect body weight, and easily to lead to low blood sugar level.
