Diabetes has become Taiwan's fifth leading cause of death.If poorly controlled, diabetes will cause many complications which are huge burden for medical expenses. The current NHI needs to consider the cost, and it is the goal to reduce the existing drug cost and achieve the best treatment. The control of diabetes should be a positive control, and good blood glucose control can reduce complications that can make health insurance medical savings sustainable development. The treatment of type II diabetes, long-acting insulin based drug control with oral hypoglycemic for the patients of poor blood glucose control is converted to twice daily premixed insulin control, which is better compared with blood sugar control effects, and costs of drug spending.