Synthesis and Spectroscopic Study of N-(4-aryl)-5-methylisoxazol-4-carboxamide and N-(4-aryl)-3-methylisoxazol-4-carboxamide

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题名:	Synthesis and Spectroscopic Study of N-(4-aryl)-5-methylisoxazol-4-carboxamide and N-(4-aryl)-3-methylisoxazol-4-carboxamide
作者:	Huei-Jia Lai
贡献者:	Department of Biotechnology
关键词:	isoxazole;N-(4-aryl)-5-methylisoxazol-4-carboxamide;N-(4-aryl)-3-methylisoxazol-4-carboxamide;SCS;long distance Hammett substituent effect
日期:	2010
上传时间:	2010-11-08 01:10:49 (UTC+0)
出版者:	Asia University
摘要:	Isoxazole is a class of heterocyclic compounds having a remarkable number of applications and has been demonstrated to be very versatile building blocks in organic synthesis. Two series of N-(4-aryl)-5-methylisoxazol-4-carboxamide and N-(4-aryl)-3-methylisoxazol-4-carboxamide were synthesized and spectroscopic studied to investigate the variation reaction on the substutents phenyl ring. The isoxazole derivatives were prepared from the reaction 5-methylisoxazole-4-carbonyl chloride or 3-methylisoxazole-4-carbonyl chloride and substituted anilines in good yields. The SCS on C-13 NMR studies on the series of N-(4-aryl)-5-methyl- isoxazol-4-carboxamide showed that the aryl substituent effect on isoxazole’s C5 via long distance Hammett substituent effect (slope = +1.3, r2 = 0.94). N-(4-aryl)-3-methylisoxazol-4-carboxamide was first synthesized and characterized by means of melting point, elemental analysis, IR, UV, EI-MS, 1H NMR spectrum and 13C NMR spectrum analysis.
显示于类别:	[生物科技學系] 博碩士論文

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