Anti-Inflammatory Activity of Sanghuangporus sanghuang Mycelium. International Journal of Molecular Sciences

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题名:	Anti-Inflammatory Activity of Sanghuangporus sanghuang Mycelium. International Journal of Molecular Sciences
作者:	Huang, Wang-Ching L；Wang-Ching Lin；鄧正賢；Jeng-Shyan Deng；Shyh-Shyun H；Shyh-Shyun Huang；Sheng-Hua Wu；Sheng-Hua Wu；Guan-Jhong H；Guan-Jhong
贡献者:	保健營養生技學系
日期:	2017-02
上传时间:	2017-12-08 06:11:30 (UTC+0)
摘要:	Acute lung injury (ALI) is characterized by inflammation of the lung tissue and oxidative injury caused by excessive accumulation of reactive oxygen species. Studies have suggested that anti-inflammatory or antioxidant agents could be used for the treatment of ALI with a good outcome. Therefore, our study aimed to test whether the mycelium extract of Sanghuangporus sanghuang (SS-1), believed to exhibit antioxidant and anti-inflammatory properties, could be used against the excessive inflammatory response associated with lipopolysaccharides (LPS)-induced ALI in mice and to investigate its possible mechanism of action. The experimental results showed that the administration of SS-1 could inhibit LPS-induced inflammation. SS-1 could reduce the number of inflammatory cells, inhibit myeloperoxidase (MPO) activity, regulate the TLR4/PI3K/Akt/mTOR pathway and the signal transduction of NF-κB and MAPK pathways in the lung tissue, and inhibit high mobility group box-1 protein 1 (HNGB1) activity in BALF. In addition, SS-1 could affect the synthesis of antioxidant enzymes Heme oxygenase 1 (HO-1) and Thioredoxin-1 (Trx-1) in the lung tissue and regulate signal transduction in the KRAB-associated protein-1 (KAP1)/nuclear factor erythroid-2-related factor Nrf2/Kelch Like ECH associated Protein 1 (Keap1) pathway. Histological results showed that administration of SS-1 prior to induction could inhibit the large-scale LPS-induced neutrophil infiltration of the lung tissue. Therefore, based on all experimental results, we propose that SS-1 exhibits a protective effect against LPS-induced ALI in mice. The mycelium of S. sanghuang can potentially be used for the treatment or prevention of inflammation-related diseases.
關聯:	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
显示于类别:	[食品營養與保健生技學系] 期刊論文

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