3D printing of cytocompatible water-based light-cured polyurethane with hyaluronic acid for cartilage tissue engineering applications

ASIAIR > College of Computer Science > Department of Biomedical informatics > Journal Article > Item 310904400/108325

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Title:	3D printing of cytocompatible water-based light-cured polyurethane with hyaluronic acid for cartilage tissue engineering applications
Authors:	謝明佑；Shie, M.-Y.；Chang, W.-C.；Chang, W.-C.；Wei, L.-J.；Wei, L.-J.；Huang, Y.-H.；Huang, Y.-H.；Chen, C.-H.；Chen, C.-H.；Shih, C.-T.；Shih, C.-T.；Chen, Y.-E.；Chen, Y.-E.；沈育芳；Yu-Fang Shen
Contributors:	生物資訊與醫學工程學系
Date:	2017-02
Issue Date:	2017-11-03 06:09:35 (UTC+0)
Abstract:	Diseases in articular cartilages have affected millions of people globally. Although the biochemical and cellular composition of articular cartilages is relatively simple, there is a limitation in the self-repair ability of the cartilage. Therefore, developing strategies for cartilage repair is very important. Here, we report on a new liquid resin preparation process of water-based polyurethane based photosensitive materials with hyaluronic acid with application of the materials for 3D printed customized cartilage scaffolds. The scaffold has high cytocompatibility and is one that closely mimics the mechanical properties of articular cartilages. It is suitable for culturing human Wharton’s jelly mesenchymal stem cells (hWJMSCs) and the cells in this case showed an excellent chondrogenic differentiation capacity. We consider that the 3D printing hybrid scaffolds may have potential in customized tissue engineering and also facilitate the development of cartilage tissue engineering.
Relation:	Materials
Appears in Collections:	[Department of Biomedical informatics ] Journal Article

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